Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs

Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the h ACE2 Receptor

The rapid and global spread of a new human coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19.

Here, we consider drug repurposing as an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. We review current information concerning the global health issue of COVID-19 including promising approved drugs, e.g., human angiotensin-converting enzyme inhibitors (hACEIs).

  • Besides, we describe computational approaches to be used in drug repurposing and highlight examples of in-silico studies of drug development efforts against SARS-CoV-2. Alacepril and lisinopril were found to interact with human angiotensin-converting enzyme 2 (hACE2), the host entranceway for SARS-CoV-2 spike protein, through exhibiting the most acceptable rmsd_refine values and the best binding affinity through forming a strong hydrogen bond with Asn90, which is assumed to be essential for the activity, as well as significant extra interactions with other receptor-binding residues.
  • Furthermore, molecular dynamics (MD) simulations followed by calculation of the binding free energy were also carried out for the most promising two ligand-pocket complexes from docking studies (alacepril and lisinopril) to clarify some information on their thermodynamic and dynamic properties and confirm the docking results as well.

These results we obtained probably provided an excellent lead candidate for the development of therapeutic drugs against COVID-19. Eventually, animal experiments and accurate clinical trials are needed to confirm the potential preventive and treatment effect of these compounds.

Revision and phylogeny of the genus Loxoneptera Hampson, 1896 (Lepidoptera, Crambidae, Pyraustinae), based on morphology and molecular data

The genus Loxoneptera Hampson, 1896 is revised based on external appearance and genitalia. It is comprised of eleven species, of which three are described as new species from China: L. crassiuncata Chen & Zhang, sp. nov.L. triangularis Chen & Zhang, sp. nov., and L. rectacerosa Chen & Zhang, sp. nov.; six species are proposed as new combinations: L. carnealis (Swinhoe, 1895), comb. nov.L. medialis (Caradja, 1925), comb. nov.L. pentasaris (Meyrick, 1932), comb. nov.L. bipunctalis (Hampson, 1912), comb. nov.L. brevipalpis (Snellen, 1890), comb. nov., and L. dichroma (Moore, 1888), comb. nov. A new replacement name, L. hampsoni Chen & Zhang, nom. nov., is proposed for L. carnealis Hampson, 1896, the type species of the genus, because it is a secondary homonym of L. carnealis (Swinhoe, 1895), comb. nov. External characters and genitalia morphology of all species are figured. Nucleotide sequences of COI, 16S rRNA, 28S rRNA, and EF-1α were used for the molecular analysis and phylogeny of Loxoneptera species.

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Ultra-high Magnification Endocytoscopy and Molecular Markers for Defining Endoscopic and Histologic Remission in Ulcerative Colitis-An Exploratory Study to Define Deep Remission

Background: Endoscopic and histological remission are both important treatment goals in patients with ulcerative colitis (UC). We aimed to define cellular architecture, expression of molecular markers, and their correlation with endoscopic scores assessed by ultra-high magnification endocytoscopy (ECS) and histological scores.

Methods: Patients with UC (n = 29) were prospectively recruited. The correlation among ECS score (ECSS), Mayo endoscopic score (MES), and histological scores were determined. Area under curve were plotted to determine the best thresholds for ECSS that predicted histological remission by Robarts (RHI) and Nancy Histological Index (NHI).

 

Soluble analytes relevant to inflammation were measured in serum and mucosal culture supernatants using ProcartaPlex Luminex assays and studied by partial least square discriminant analysis and logistic model. Mucosal RNA sequencing and bioinformatics analysis were performed to define differentially expressed genes/pathways.

Results: Endocytoscope scoring system correlated strongly with RHI (r = 0.89; 95% CI, 0.51-0.98) and NHI (r = 0.86; 95% CI, 0.42-0.98) but correlated poorly with MES (r = 0.28; 95% CI, 0.27-0.70). We identified soluble brain-derived neurotrophic factors (BDNF), macrophage inflammatory proteins (MIP-1 α), and soluble vascular cell adhesion molecule 1 (sVCAM-1) predicted histological remission.

Mucosal biopsy cultures also identified sVCAM-1 associated with healed mucosa. RNA-seq analysis identified gene expressions shared between ECSS, RHI, or NHI defined healing. A number of gene expressions and pathways were identified including inflammation and metabolic and tumor suppressors that discriminated healed from nonhealed mucosa.

Conclusions: Endocytoscopy represents an interesting tool that may sit between endoscopy and histology-but closer to the latter-identifying gene expression markers and pathways that are also identified by histology.

Keywords: RNA-sequencing; endocytoscope; histological healing; mucosal healing; noninvasive markers.

 

PDGFR

ABF5489 100 ug
EUR 525.6

PDGFR

ABF8053 100 ug
EUR 525.6

PDGFR

EF007051 96 Tests
EUR 826.8

PDGFR alpha antibody

70R-50185 100 ul
EUR 292.8
Description: Purified Polyclonal PDGFR alpha antibody

PDGFR beta antibody

70R-50186 100 ul
EUR 292.8
Description: Purified Polyclonal PDGFR beta antibody

PDGFR alpha antibody

70R-33642 100 ug
EUR 392.4
Description: Rabbit polyclonal PDGFR alpha antibody

PDGFR alpha antibody

70R-33644 100 ug
EUR 392.4
Description: Rabbit polyclonal PDGFR alpha antibody

PDGFR beta antibody

70R-33646 100 ug
EUR 392.4
Description: Rabbit polyclonal PDGFR beta antibody

PDGFR beta antibody

70R-33648 100 ug
EUR 392.4
Description: Rabbit polyclonal PDGFR beta antibody

PDGFR beta antibody

70R-51313 100 ul
EUR 344.4
Description: Purified Polyclonal PDGFR beta antibody

PDGFR alpha antibody

70R-30719 100 ug
EUR 392.4
Description: Rabbit polyclonal PDGFR alpha antibody

PDGFR alpha Antibody

49363-100ul 100ul
EUR 399.6

PDGFR alpha Antibody

49363-50ul 50ul
EUR 286.8

PDGFR α Antibody

33470-100ul 100ul
EUR 302.4

PDGFR α Antibody

33470-50ul 50ul
EUR 224.4

PDGFr beta antibody

10R-1809 100 ul
EUR 483.6
Description: Mouse monoclonal PDGFr beta antibody

PDGFR beta Antibody

ABF6132 100 ug
EUR 525.6

PDGFR beta Antibody

ABF6133 100 ug
EUR 525.6

PDGFR-? Polyclonal Antibody

ES3165-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3165-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3166-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3166-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3751-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3751-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3995-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES3995-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGFR ? Polyclonal Antibody

ES8919-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR ? Polyclonal Antibody

ES8919-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR ? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6534-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6534-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6535-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6535-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6536-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6536-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6537-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6537-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6544-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6544-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6545-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6545-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6546-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGFR-? Polyclonal Antibody

ES6546-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PDGFR-? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

PDGFR alpha Antibody

F50656-0.4ML 0.4 ml
EUR 379

PDGFR Antibody (CD140b)

F40302-0.4ML 0.4 ml
EUR 379

Monoclonal PDGFRB / PDGFR Beta Antibody (clone 42G12), Clone: 42G12

AMM01839G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human PDGFRB / PDGFR Beta (clone 42G12). The antibodies are raised in Mouse and are from clone 42G12. This antibody is applicable in WB and IHC-P

PDGFR alpha antibody (Tyr754)

70R-33643 100 ug
EUR 392.4
Description: Rabbit polyclonal PDGFR alpha antibody (Tyr754)

PDGFR beta antibody (Tyr740)

70R-33645 100 ug
EUR 392.4
Description: Rabbit polyclonal PDGFR beta antibody (Tyr740)

PDGFR beta antibody (Tyr1021)

70R-33647 100 ug
EUR 392.4
Description: Rabbit polyclonal PDGFR beta antibody (Tyr1021)

PDGFR-β Polyclonal Antibody

41327-100ul 100ul
EUR 302.4

PDGFR-β Polyclonal Antibody

41327-50ul 50ul
EUR 224.4

PDGFR-α Polyclonal Antibody

41672-100ul 100ul
EUR 302.4

PDGFR-α Polyclonal Antibody

41672-50ul 50ul
EUR 224.4

Anti-PDGFR alpha Antibody

A30446 100ul
EUR 476.4
Description: Rabbit Polyclonal PDGFR alpha Antibody. Validated in IF, IHC and tested in Human, Mouse, Rat.

PDGFR-Alpha Polyclonal Antibody

ABP55535-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754

PDGFR-Alpha Polyclonal Antibody

ABP55535-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754

PDGFR-Alpha Polyclonal Antibody

ABP55535-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y754

PDGFR-Alpha Polyclonal Antibody

ABP55536-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849

PDGFR-Alpha Polyclonal Antibody

ABP55536-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849

PDGFR-Alpha Polyclonal Antibody

ABP55536-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y849

PDGFR-Alpha Polyclonal Antibody

ABP55537-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018

PDGFR-Alpha Polyclonal Antibody

ABP55537-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018

PDGFR-Alpha Polyclonal Antibody

ABP55537-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1018

PDGFR-Alpha Polyclonal Antibody

ABP55538-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762

PDGFR-Alpha Polyclonal Antibody

ABP55538-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762

PDGFR-Alpha Polyclonal Antibody

ABP55538-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y762

PDGFR-Beta Polyclonal Antibody

ABP55545-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody

ABP55545-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody

ABP55545-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1009

PDGFR-Beta Polyclonal Antibody

ABP55546-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody

ABP55546-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody

ABP55546-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y1021

PDGFR-Beta Polyclonal Antibody

ABP55547-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR-Beta Polyclonal Antibody

ABP55547-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR-Beta Polyclonal Antibody

ABP55547-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y740

PDGFR beta (pY751) Antibody

20-abx133055
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

PDGFR-Alpha Polyclonal Antibody

ABP52166-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090

PDGFR-Alpha Polyclonal Antibody

ABP52166-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090

PDGFR-Alpha Polyclonal Antibody

ABP52166-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human PDGFR-? at AA range: 1010-1090

PDGFR-Beta Polyclonal Antibody

ABP52167-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody

ABP52167-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody

ABP52167-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Mouse, Rat. This PDGFR-Beta antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y751

PDGFR-Beta Polyclonal Antibody

ABP52752-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

PDGFR-Beta Polyclonal Antibody

ABP52752-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

PDGFR-Beta Polyclonal Antibody

ABP52752-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Beta from Human, Rat. This PDGFR-Beta antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PDGFR-? around the non-phosphorylation site of Y771

PDGFR-Alpha Polyclonal Antibody

ABP52996-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?

PDGFR-Alpha Polyclonal Antibody

ABP52996-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?

PDGFR-Alpha Polyclonal Antibody

ABP52996-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR-Alpha from Human, Mouse, Rat. This PDGFR-Alpha antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PDGFR-?

PDGFR Alpha Polyclonal Antibody

ABP59867-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein

PDGFR Alpha Polyclonal Antibody

ABP59867-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein

PDGFR Alpha Polyclonal Antibody

ABP59867-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PDGFR Alpha from Human, Mouse, Rat. This PDGFR Alpha antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human PDGFR ? protein

PDGFR beta (pT1009) Antibody

20-abx009684
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

PDGFR beta (pY1021) Antibody

abx011955-100ug 100 ug
EUR 526.8

PDGFR beta (pY740) Antibody

abx011959-100ug 100 ug
EUR 526.8

Anti-PDGFR-beta Antibody

A1994-100 100 µl
EUR 405.6

PDGFR alpha (pY762) Antibody

abx217685-100ug 100 ug
EUR 526.8

PDGFR α Conjugated Antibody

C33470 100ul
EUR 476.4

PDGFR alpha Conjugated Antibody

C49363 100ul
EUR 476.4

Anti-PDGFR-alpha antibody

STJ94997 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody

STJ94998 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody

STJ94999 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody

STJ95000 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-alpha antibody

STJ95001 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-alpha.

Anti-PDGFR-beta antibody

STJ95002 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-beta.

Anti-PDGFR-beta antibody

STJ95003 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-beta.

Anti-PDGFR-beta antibody

STJ95004 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-beta.

Anti-PDGFR-beta antibody

STJ95005 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-beta.

Anti-PDGFR-beta antibody

STJ98314 100 µl
EUR 280.8
Description: Mouse monoclonal to PDGFR-beta.

Anti-PDGFR alpha antibody

STJ99637 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR alpha.

Anti-PDGFR-beta antibody

STJ96376 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-beta.

Anti-PDGFR-alpha antibody

STJ96630 200 µl
EUR 236.4
Description: Rabbit polyclonal to PDGFR-alpha.

Cellular and Molecular Processes in Pulmonary Hypertension

Pulmonary hypertension (PH) is a progressive lung disease characterized by persistent pulmonary vasoconstriction. Another well-recognized characteristic of PH is the muscularization of peripheral pulmonary arteries.

This pulmonary vasoremodeling manifests in medial hypertrophy/hyperplasia of smooth muscle cells (SMCs) with possible neointimal formation. The underlying molecular processes for these two major vascular responses remain not fully understood.

On the other hand, a series of very recent studies have shown that the increased reactive oxygen species (ROS) seems to be an important player in mediating pulmonary vasoconstriction and vasoremodeling, thereby leading to PH. Mitochondria are a primary site for ROS production in pulmonary artery (PA) SMCs, which subsequently activate NADPH oxidase to induce further ROS generation, i.e., ROS-induced ROS generation.

ROS control the activity of multiple ion channels to induce intracellular Ca2+ release and extracellular Ca2+ influx (ROS-induced Ca2+ release and influx) to cause PH. ROS and Ca2+ signaling may synergistically trigger an inflammatory cascade to implicate in PH.

Accordingly, this paper explores the important roles of ROS, Ca2+, and inflammatory signaling in the development of PH, including their reciprocal interactions, key molecules, and possible therapeutic targets.

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