Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs

Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the h ACE2 Receptor

The rapid and global spread of a new human coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19.

Here, we consider drug repurposing as an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. We review current information concerning the global health issue of COVID-19 including promising approved drugs, e.g., human angiotensin-converting enzyme inhibitors (hACEIs).

  • Besides, we describe computational approaches to be used in drug repurposing and highlight examples of in-silico studies of drug development efforts against SARS-CoV-2. Alacepril and lisinopril were found to interact with human angiotensin-converting enzyme 2 (hACE2), the host entranceway for SARS-CoV-2 spike protein, through exhibiting the most acceptable rmsd_refine values and the best binding affinity through forming a strong hydrogen bond with Asn90, which is assumed to be essential for the activity, as well as significant extra interactions with other receptor-binding residues.
  • Furthermore, molecular dynamics (MD) simulations followed by calculation of the binding free energy were also carried out for the most promising two ligand-pocket complexes from docking studies (alacepril and lisinopril) to clarify some information on their thermodynamic and dynamic properties and confirm the docking results as well.

These results we obtained probably provided an excellent lead candidate for the development of therapeutic drugs against COVID-19. Eventually, animal experiments and accurate clinical trials are needed to confirm the potential preventive and treatment effect of these compounds.

Revision and phylogeny of the genus Loxoneptera Hampson, 1896 (Lepidoptera, Crambidae, Pyraustinae), based on morphology and molecular data

The genus Loxoneptera Hampson, 1896 is revised based on external appearance and genitalia. It is comprised of eleven species, of which three are described as new species from China: L. crassiuncata Chen & Zhang, sp. nov.L. triangularis Chen & Zhang, sp. nov., and L. rectacerosa Chen & Zhang, sp. nov.; six species are proposed as new combinations: L. carnealis (Swinhoe, 1895), comb. nov.L. medialis (Caradja, 1925), comb. nov.L. pentasaris (Meyrick, 1932), comb. nov.L. bipunctalis (Hampson, 1912), comb. nov.L. brevipalpis (Snellen, 1890), comb. nov., and L. dichroma (Moore, 1888), comb. nov. A new replacement name, L. hampsoni Chen & Zhang, nom. nov., is proposed for L. carnealis Hampson, 1896, the type species of the genus, because it is a secondary homonym of L. carnealis (Swinhoe, 1895), comb. nov. External characters and genitalia morphology of all species are figured. Nucleotide sequences of COI, 16S rRNA, 28S rRNA, and EF-1α were used for the molecular analysis and phylogeny of Loxoneptera species.

xceedmolecular
xceedmolecular

Ultra-high Magnification Endocytoscopy and Molecular Markers for Defining Endoscopic and Histologic Remission in Ulcerative Colitis-An Exploratory Study to Define Deep Remission

Background: Endoscopic and histological remission are both important treatment goals in patients with ulcerative colitis (UC). We aimed to define cellular architecture, expression of molecular markers, and their correlation with endoscopic scores assessed by ultra-high magnification endocytoscopy (ECS) and histological scores.

Methods: Patients with UC (n = 29) were prospectively recruited. The correlation among ECS score (ECSS), Mayo endoscopic score (MES), and histological scores were determined. Area under curve were plotted to determine the best thresholds for ECSS that predicted histological remission by Robarts (RHI) and Nancy Histological Index (NHI).

 

Soluble analytes relevant to inflammation were measured in serum and mucosal culture supernatants using ProcartaPlex Luminex assays and studied by partial least square discriminant analysis and logistic model. Mucosal RNA sequencing and bioinformatics analysis were performed to define differentially expressed genes/pathways.

Results: Endocytoscope scoring system correlated strongly with RHI (r = 0.89; 95% CI, 0.51-0.98) and NHI (r = 0.86; 95% CI, 0.42-0.98) but correlated poorly with MES (r = 0.28; 95% CI, 0.27-0.70). We identified soluble brain-derived neurotrophic factors (BDNF), macrophage inflammatory proteins (MIP-1 α), and soluble vascular cell adhesion molecule 1 (sVCAM-1) predicted histological remission.

Mucosal biopsy cultures also identified sVCAM-1 associated with healed mucosa. RNA-seq analysis identified gene expressions shared between ECSS, RHI, or NHI defined healing. A number of gene expressions and pathways were identified including inflammation and metabolic and tumor suppressors that discriminated healed from nonhealed mucosa.

Conclusions: Endocytoscopy represents an interesting tool that may sit between endoscopy and histology-but closer to the latter-identifying gene expression markers and pathways that are also identified by histology.

Keywords: RNA-sequencing; endocytoscope; histological healing; mucosal healing; noninvasive markers.

 

PDGFR Alpha mouse Monoclonal Antibody(7A3)

BT-MCA1011-20ul 20ul Ask for price
Description: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

PDGFR Alpha mouse Monoclonal Antibody(7A3)

BT-MCA1011-50ul 50ul Ask for price
Description: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

PDGFR Alpha mouse Monoclonal Antibody(4G11)

BT-MCA1010-100ul 100ul Ask for price
Description: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

PDGFR Alpha mouse Monoclonal Antibody(4G11)

BT-MCA1010-20ul 20ul Ask for price
Description: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

PDGFR Alpha mouse Monoclonal Antibody(4G11)

BT-MCA1010-50ul 50ul Ask for price
Description: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

Monoclonal PDGFRB / PDGFR Beta Antibody (clone 42G12), Clone: 42G12

AMM01839G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human PDGFRB / PDGFR Beta (clone 42G12). The antibodies are raised in Mouse and are from clone 42G12. This antibody is applicable in WB and IHC-P

Mouse monoclonal Anti-PDGFR alpha Clone PDGFR-H7A

TA353378L 500 µg Ask for price

Anti-Erbitux Monoclonal Antibody (1415CT827.43.14)

MBS9232237-01mL 0.1mL
EUR 445

Anti-Erbitux Monoclonal Antibody (1415CT827.43.14)

MBS9232237-5x01mL 5x0.1mL
EUR 1665

Monoclonal T Antibody, Clone: 394CT14.1.4

AMM02391G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human T. The antibodies are raised in Mouse and are from clone 394CT14.1.4. This antibody is applicable in WB, E

Anti-Remicade Monoclonal Antibody (1401CT484.58.53)

MBS9232235-01mL 0.1mL
EUR 445

Anti-Remicade Monoclonal Antibody (1401CT484.58.53)

MBS9232235-5x01mL 5x0.1mL
EUR 1665

Anti-Herceptin Monoclonal Antibody (1402CT551.4.30)

MBS9232233-01mL 0.1mL
EUR 445

Anti-Herceptin Monoclonal Antibody (1402CT551.4.30)

MBS9232233-5x01mL 5x0.1mL
EUR 1665

Anti-Inflixmab Monoclonal Antibody (1401CT111.9.32)

MBS9232234-01mL 0.1mL
EUR 445

Anti-Inflixmab Monoclonal Antibody (1401CT111.9.32)

MBS9232234-5x01mL 5x0.1mL
EUR 1665

Anti-Cetuximab Monoclonal Antibody (1415CT546.39.94)

MBS9232236-01mL 0.1mL
EUR 445

Anti-Cetuximab Monoclonal Antibody (1415CT546.39.94)

MBS9232236-5x01mL 5x0.1mL
EUR 1665

Rat Monoclonal anti-mouse PDGFR beta

mAP-0005 100ug
EUR 250

Monoclonal FYN Antibody, Clone: 1302CT390.118.237

AMM02485G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human FYN. The antibodies are raised in Mouse and are from clone 1302CT390.118.237. This antibody is applicable in WB, FC, IHC-P, E

Monoclonal JUN antibody , Clone: 1306CT545.208.117

AMM02503G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human JUN . The antibodies are raised in Mouse and are from clone 1306CT545.208.117. This antibody is applicable in WB, E

Monoclonal VCP Antibody, Clone: 1344CT150.163.114

APR10678G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human VCP. The antibodies are raised in Mouse and are from clone 1344CT150.163.114. This antibody is applicable in WB and IF, E

Monoclonal PHB Antibody, Clone: 1215CT487.109.106

APR09107G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human PHB. The antibodies are raised in Mouse and are from clone 1215CT487.109.106. This antibody is applicable in WB and IHC-P, E

Monoclonal SP1 Antibody, Clone: 1326CT463.109.176

APR10209G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human SP1. The antibodies are raised in Mouse and are from clone 1326CT463.109.176. This antibody is applicable in WB, FC, IF, E

Anti-Trastuzumab Monoclonal Antibody (1402CT432.13.33.67)

MBS9232232-01mL 0.1mL
EUR 445

Anti-Trastuzumab Monoclonal Antibody (1402CT432.13.33.67)

MBS9232232-5x01mL 5x0.1mL
EUR 1665

Mouse Monoclonal anti-human PDGFR beta

hAP-0005A 100ug
EUR 250

Monoclonal CD74 Antibody, Clone: 1267CT820.116.140.154

AMM02483G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CD74. The antibodies are raised in Mouse and are from clone 1267CT820.116.140.154. This antibody is applicable in WB, FC, E

Monoclonal USP5 Antibody, Clone: 1340CT704.170.140

AMM02502G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human USP5. The antibodies are raised in Mouse and are from clone 1340CT704.170.140. This antibody is applicable in WB, E

Monoclonal RAC1 Antibody, Clone: 1301CT276.121.104

AMM02510G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RAC1. The antibodies are raised in Mouse and are from clone 1301CT276.121.104. This antibody is applicable in WB, FC, IHC-P, E

Monoclonal WNT4 Antibody, Clone: 1698CT540.169.185

AMM02561G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human WNT4. The antibodies are raised in Mouse and are from clone 1698CT540.169.185. This antibody is applicable in WB, E

Monoclonal ATG5 Antibody, Clone: 1358CT289.125.123

APG02061G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human ATG5. The antibodies are raised in Mouse and are from clone 1358CT289.125.123. This antibody is applicable in WB, E

Monoclonal CDK5 Antibody, Clone: 1321CT281.130.129

APG02513G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CDK5. The antibodies are raised in Mouse and are from clone 1321CT281.130.129. This antibody is applicable in WB, E

Monoclonal CDK5 Antibody, Clone: 1321CT281.130.129

APG02514G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CDK5. The antibodies are raised in Mouse and are from clone 1321CT281.130.129. This antibody is applicable in WB, E

Monoclonal FLNA Antibody, Clone: 1273CT424.104.153

APR14335G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human FLNA. The antibodies are raised in Mouse and are from clone 1273CT424.104.153. This antibody is applicable in WB, E

Monoclonal SRC Antibody, Clone: 1602CT774.225.92

AMM02550G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human SRC. The antibodies are raised in Mouse and are from clone 1602CT774.225.92. This antibody is applicable in WB, E

Monoclonal CD138 Antibody, Clone: 531CT15.4.1;531CT15.1.4

APG02477G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CD138. The antibodies are raised in Mouse and are from clone 531CT15.4.1;531CT15.1.4. This antibody is applicable in WB, E

Mouse Monoclonal anti-human PDGFR Alpha

hAP-0004A 100ug
EUR 250

Monoclonal CREB1 Antibody, Clone: 1335CT115.203.189

AMM02443G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CREB1. The antibodies are raised in Mouse and are from clone 1335CT115.203.189. This antibody is applicable in WB, E

Monoclonal NFKB1 Antibody, Clone: 1298CT792.105.117.133

AMM02481G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human NFKB1. The antibodies are raised in Mouse and are from clone 1298CT792.105.117.133. This antibody is applicable in WB, FC, IHC-P, E

Monoclonal USP25 Antibody, Clone: 1277CT376.106.171

AMM02482G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human USP25. The antibodies are raised in Mouse and are from clone 1277CT376.106.171. This antibody is applicable in WB, E

Monoclonal AURKA Antibody, Clone: 1364CT291.108.155

AMM02504G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human AURKA . The antibodies are raised in Mouse and are from clone 1364CT291.108.155. This antibody is applicable in WB and IHC-P, E

Monoclonal APEX1 Antibody, Clone: 1518CT337.123.86.269.232

AMM02531G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human APEX1. The antibodies are raised in Mouse and are from clone 1518CT337.123.86.269.232. This antibody is applicable in IF, IHC-P, WB, E

Monoclonal Stat3 antibody, Clone: 1200CT146.104.153

APR11193G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human Stat3. The antibodies are raised in Mouse and are from clone 1200CT146.104.153. This antibody is applicable in WB, E

Monoclonal STAT3 Antibody, Clone: 1200CT146.104.153

APR11194G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human STAT3. The antibodies are raised in Mouse and are from clone 1200CT146.104.153. This antibody is applicable in WB, E

Monoclonal EPHA6 Antibody, Clone: 1426CT591.205.91.119

APR11872G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human EPHA6. The antibodies are raised in Mouse and are from clone 1426CT591.205.91.119. This antibody is applicable in WB, E

Monoclonal PPARA Antibody, Clone: 1331CT894.186.143

AMR09449G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human PPARA. The antibodies are raised in Mouse and are from clone 1331CT894.186.143. This antibody is applicable in WB, FC, IF, IHC-P, E

Monoclonal CRYAB Antibody, Clone: 1329CT523.140.120

APG02805G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CRYAB. The antibodies are raised in Mouse and are from clone 1329CT523.140.120. This antibody is applicable in WB, E

Monoclonal YWHAZ Antibody, Clone: 1314CT423.108.153.173.140

APR14004G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human YWHAZ. The antibodies are raised in Mouse and are from clone 1314CT423.108.153.173.140. This antibody is applicable in WB and IF, E

Monoclonal CDK4 Antibody, Clone: 1529CT850.162.73

AMM02527G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CDK4. The antibodies are raised in Mouse and are from clone 1529CT850.162.73. This antibody is applicable in IHC-P, WB, E

Monoclonal VAV1 Antibody, Clone: 1582CT802.383.58

AMM02536G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human VAV1. The antibodies are raised in Mouse and are from clone 1582CT802.383.58. This antibody is applicable in WB, E

Monoclonal MITF Antibody, Clone: 1607CT834.207.47

AMM02540G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human MITF. The antibodies are raised in Mouse and are from clone 1607CT834.207.47. This antibody is applicable in WB, E

Monoclonal SUFU Antibody, Clone: 1783CT536.263.29

AMM02579G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human SUFU. The antibodies are raised in Mouse and are from clone 1783CT536.263.29. This antibody is applicable in WB, E

Monoclonal GLS2 Antibody, Clone: 1758CT879.217.60

AMM04798G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human GLS2. The antibodies are raised in Mouse and are from clone 1758CT879.217.60. This antibody is applicable in WB, E

Monoclonal AKT2 Antibody, Clone: 1623CT791.157.67.66

APG01699G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human AKT2. The antibodies are raised in Mouse and are from clone 1623CT791.157.67.66. This antibody is applicable in WB, E

Monoclonal CDK5 Antibody, Clone: 1552CT262.105.8

APG02512G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CDK5. The antibodies are raised in Mouse and are from clone 1552CT262.105.8. This antibody is applicable in IF, FC, IHC-P, WB, E

Monoclonal Musk Antibody, Clone: 1429CT456.173.44

APR17485G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human Musk. The antibodies are raised in Mouse and are from clone 1429CT456.173.44. This antibody is applicable in WB and IHC-P, E

Anti Beta-Estradiol Monoclonal Antibody (1977CT128.130.83)

MBS9232240-01mL 0.1mL
EUR 445

Anti Beta-Estradiol Monoclonal Antibody (1977CT128.130.83)

MBS9232240-5x01mL 5x0.1mL
EUR 1665

Monoclonal FER Antibody, Clone: 1457CT181.12.17

AMM02516G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human FER. The antibodies are raised in Mouse and are from clone 1457CT181.12.17. This antibody is applicable in IHC-P, WB, E

Monoclonal FZR Antibody, Clone: 1621CT637.76.67

AMM02543G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human FZR. The antibodies are raised in Mouse and are from clone 1621CT637.76.67. This antibody is applicable in WB, E

Monoclonal P53 Antibody, Clone: 1711CT184.18.1

AMM02567G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human P53. The antibodies are raised in Mouse and are from clone 1711CT184.18.1. This antibody is applicable in WB, E

Monoclonal CBL Antibody, Clone: 1762CT401.80.60

AMM02574G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CBL. The antibodies are raised in Mouse and are from clone 1762CT401.80.60. This antibody is applicable in WB, E

Monoclonal MYC Antibody, Clone: 1788CT320.61.28

AMM02578G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human MYC. The antibodies are raised in Mouse and are from clone 1788CT320.61.28. This antibody is applicable in WB, E

Monoclonal VCP Antibody, Clone: 1563CT163.48.77

APR10677G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human VCP. The antibodies are raised in Mouse and are from clone 1563CT163.48.77. This antibody is applicable in WB and IHC-P, IF, FC, E

Monoclonal RYK Antibody, Clone: 1671CT575.42.61

AMM07703G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RYK. The antibodies are raised in Mouse and are from clone 1671CT575.42.61. This antibody is applicable in FC, WB, E

Monoclonal HCK Antibody, Clone: 1508CT602.13.1

APR16661G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human HCK. The antibodies are raised in Mouse and are from clone 1508CT602.13.1. This antibody is applicable in IF, WB, E

Monoclonal LCK Antibody, Clone: 1526CT823.75.16

APR17161G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human LCK. The antibodies are raised in Mouse and are from clone 1526CT823.75.16. This antibody is applicable in IF, FC, IHC-P, WB, E

Monoclonal CDKN1B Antibody, Clone: 1373CT407.103.103

AMM02509G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CDKN1B. The antibodies are raised in Mouse and are from clone 1373CT407.103.103. This antibody is applicable in WB and IHC-P, E

Monoclonal DPYSL5 Antibody, Clone: 1503CT789.209.250.52

APR11785G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human DPYSL5. The antibodies are raised in Mouse and are from clone 1503CT789.209.250.52. This antibody is applicable in IF, WB, E

Monoclonal SQSTM1 Antibody, Clone: 1336CT763.152.125

APR10230G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human SQSTM1. The antibodies are raised in Mouse and are from clone 1336CT763.152.125. This antibody is applicable in WB, E

Monoclonal RPTOR Antibody, Clone: 1411CT316.2.151.34

AMM02512G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RPTOR. The antibodies are raised in Mouse and are from clone 1411CT316.2.151.34. This antibody is applicable in WB and IHC-P, E

Monoclonal TIMP2 Antibody, Clone: 1554CT494.262.47

AMM02532G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human TIMP2. The antibodies are raised in Mouse and are from clone 1554CT494.262.47. This antibody is applicable in IF, FC, IHC-P, WB, E

Monoclonal RNF20 Antibody, Clone: 1594CT552.128.36

AMM02538G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RNF20. The antibodies are raised in Mouse and are from clone 1594CT552.128.36. This antibody is applicable in WB, E

Monoclonal RRAS2 Antibody, Clone: 1578CT130.349.47.14

AMM02539G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RRAS2. The antibodies are raised in Mouse and are from clone 1578CT130.349.47.14. This antibody is applicable in WB, E

Monoclonal CADH1 Antibody, Clone: 1579CT577.150.80

AMM02546G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CADH1. The antibodies are raised in Mouse and are from clone 1579CT577.150.80. This antibody is applicable in IHC-P, WB, E

Monoclonal RAB20 Antibody, Clone: 1694CT210.142.16

AMM02558G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RAB20. The antibodies are raised in Mouse and are from clone 1694CT210.142.16. This antibody is applicable in WB, E

Monoclonal RAB20 Antibody, Clone: 1694CT210.218.54

AMM02559G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RAB20. The antibodies are raised in Mouse and are from clone 1694CT210.218.54. This antibody is applicable in FC, WB, E

Monoclonal MKRN2 Antibody, Clone: 1556CT631.230.55.49

AMM06406G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human MKRN2. The antibodies are raised in Mouse and are from clone 1556CT631.230.55.49. This antibody is applicable in IHC-P, FC, WB, E

Monoclonal RAB18 Antibody, Clone: 1573CT811.119.39

AMM07448G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RAB18. The antibodies are raised in Mouse and are from clone 1573CT811.119.39. This antibody is applicable in FC, WB, E

Monoclonal DDR1 Antibody, Clone: 1464CT339.1.54

AMM02518G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human DDR1. The antibodies are raised in Mouse and are from clone 1464CT339.1.54. This antibody is applicable in IHC-P, WB, E

Monoclonal CDK2 Antibody, Clone: 1534CT665.36.16

AMM02524G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CDK2. The antibodies are raised in Mouse and are from clone 1534CT665.36.16. This antibody is applicable in WB, E

Monoclonal IRF3 Antibody, Clone: 1522CT766.58.24

AMM02526G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human IRF3. The antibodies are raised in Mouse and are from clone 1522CT766.58.24. This antibody is applicable in IF, FC, IHC-P, WB, E

Monoclonal YES1 Antibody, Clone: 1612CT505.7.50

AMM02541G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human YES1. The antibodies are raised in Mouse and are from clone 1612CT505.7.50. This antibody is applicable in WB, E

Monoclonal ETS1 Antibody, Clone: 1601CT512.35.61

AMM02542G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human ETS1. The antibodies are raised in Mouse and are from clone 1601CT512.35.61. This antibody is applicable in FC, WB, E

Monoclonal CDK1 Antibody, Clone: 1644CT107.30.27

AMM02548G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CDK1. The antibodies are raised in Mouse and are from clone 1644CT107.30.27. This antibody is applicable in WB, E

Monoclonal FAT1 Antibody, Clone: 1634CT464.1.9

AMM02549G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human FAT1. The antibodies are raised in Mouse and are from clone 1634CT464.1.9. This antibody is applicable in WB, E

Monoclonal FAT4 Antibody, Clone: 1654CT645.1.70

AMM02551G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human FAT4. The antibodies are raised in Mouse and are from clone 1654CT645.1.70. This antibody is applicable in WB, E

Monoclonal TPM3 Antibody, Clone: 1649CT306.29.13

AMM02552G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human TPM3. The antibodies are raised in Mouse and are from clone 1649CT306.29.13. This antibody is applicable in WB, E

Monoclonal PCNA Antibody, Clone: 1655CT506.10.26

AMM02554G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human PCNA. The antibodies are raised in Mouse and are from clone 1655CT506.10.26. This antibody is applicable in IHC-P, FC, WB, E

Monoclonal CYLD Antibody, Clone: 1667CT857.3.6.1

AMM02557G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CYLD. The antibodies are raised in Mouse and are from clone 1667CT857.3.6.1. This antibody is applicable in FC, WB, E

Monoclonal RELB Antibody, Clone: 1684CT450.20.25

AMM02563G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RELB. The antibodies are raised in Mouse and are from clone 1684CT450.20.25. This antibody is applicable in WB, E

Monoclonal ECT2 Antibody, Clone: 1691CT516.3.3

AMM02569G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human ECT2. The antibodies are raised in Mouse and are from clone 1691CT516.3.3. This antibody is applicable in WB, E

Monoclonal TPX2 Antibody, Clone: 1696CT464.66.9

AMM02570G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human TPX2. The antibodies are raised in Mouse and are from clone 1696CT464.66.9. This antibody is applicable in WB, E

Monoclonal USP2 Antibody, Clone: 1738CT331.50.87

AMM02572G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human USP2. The antibodies are raised in Mouse and are from clone 1738CT331.50.87. This antibody is applicable in WB, E

Monoclonal NPPA Antibody, Clone: 1761CT158.12.76

AMM02575G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human NPPA. The antibodies are raised in Mouse and are from clone 1761CT158.12.76. This antibody is applicable in WB, E

Monoclonal CD81 Antibody, Clone: 1668CT178.9.24.87

APR11034G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CD81. The antibodies are raised in Mouse and are from clone 1668CT178.9.24.87. This antibody is applicable in WB, E

Monoclonal CD81 Antibody, Clone: 1668CT146.84.1

APR11035G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CD81. The antibodies are raised in Mouse and are from clone 1668CT146.84.1. This antibody is applicable in WB, E

Monoclonal CD81 Antibody, Clone: 1668CT270.93.9

APR11037G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human CD81. The antibodies are raised in Mouse and are from clone 1668CT270.93.9. This antibody is applicable in WB, E

Monoclonal AATK Antibody, Clone: 1459CT852.80.10

AMM05526G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human AATK. The antibodies are raised in Mouse and are from clone 1459CT852.80.10. This antibody is applicable in WB and IHC-P, E

Monoclonal AGXT Antibody, Clone: 1739CT804.82.83.1

APG01616G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human AGXT. The antibodies are raised in Mouse and are from clone 1739CT804.82.83.1. This antibody is applicable in WB, E

Monoclonal ATG3 Antibody, Clone: 1377CT239.6.1.12

APG02037G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human ATG3. The antibodies are raised in Mouse and are from clone 1377CT239.6.1.12. This antibody is applicable in WB and IHC-P, E

Monoclonal SODM Antibody, Clone: 1559CT572.3.83

APR10202G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human SODM. The antibodies are raised in Mouse and are from clone 1559CT572.3.83. This antibody is applicable in FC, IHC-P, WB, E

Monoclonal LAP2 Antibody, Clone: 1617CT859.9.32

APR17152G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human LAP2. The antibodies are raised in Mouse and are from clone 1617CT859.9.32. This antibody is applicable in WB, E

Monoclonal PPP2R1B Antibody, Clone: 1496CT356.164.25.226

AMM02520G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human PPP2R1B. The antibodies are raised in Mouse and are from clone 1496CT356.164.25.226. This antibody is applicable in IF, IHC-P, FC, WB, E

Monoclonal EEF1E1 Antibody, Clone: 1494CT639.147.31

AMM02522G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human EEF1E1. The antibodies are raised in Mouse and are from clone 1494CT639.147.31. This antibody is applicable in IF, FC, WB, E

Monoclonal DAB2IP Antibody, Clone: 1626CT702.263.21

AMM02544G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human DAB2IP. The antibodies are raised in Mouse and are from clone 1626CT702.263.21. This antibody is applicable in WB, E

Monoclonal RAB27A Antibody, Clone: 1590CT813.266.26

AMM07444G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RAB27A. The antibodies are raised in Mouse and are from clone 1590CT813.266.26. This antibody is applicable in FC, WB, E

Monoclonal RAB27B Antibody, Clone: 1596CT245.254.49

AMM07459G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human RAB27B. The antibodies are raised in Mouse and are from clone 1596CT245.254.49. This antibody is applicable in FC, WB, E

Monoclonal LYN Antibody, Clone: 1174CT22.3.1.1

APR17259G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human LYN. The antibodies are raised in Mouse and are from clone 1174CT22.3.1.1. This antibody is applicable in WB, E

Cellular and Molecular Processes in Pulmonary Hypertension

Pulmonary hypertension (PH) is a progressive lung disease characterized by persistent pulmonary vasoconstriction. Another well-recognized characteristic of PH is the muscularization of peripheral pulmonary arteries.

This pulmonary vasoremodeling manifests in medial hypertrophy/hyperplasia of smooth muscle cells (SMCs) with possible neointimal formation. The underlying molecular processes for these two major vascular responses remain not fully understood.

On the other hand, a series of very recent studies have shown that the increased reactive oxygen species (ROS) seems to be an important player in mediating pulmonary vasoconstriction and vasoremodeling, thereby leading to PH. Mitochondria are a primary site for ROS production in pulmonary artery (PA) SMCs, which subsequently activate NADPH oxidase to induce further ROS generation, i.e., ROS-induced ROS generation.

ROS control the activity of multiple ion channels to induce intracellular Ca2+ release and extracellular Ca2+ influx (ROS-induced Ca2+ release and influx) to cause PH. ROS and Ca2+ signaling may synergistically trigger an inflammatory cascade to implicate in PH.

Accordingly, this paper explores the important roles of ROS, Ca2+, and inflammatory signaling in the development of PH, including their reciprocal interactions, key molecules, and possible therapeutic targets.

Leave a Reply

Your email address will not be published. Required fields are marked *