Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations

Herein we evaluated a series of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a rare neoplasm, to characterize their morphology, genomics, and behavior. Patients ranged from 27 to 73 (median 52) years and tumors from 4 to 15 (median 9) cm, with extrauterine disease noted in two.

Follow-up (median 16 months) was available for 14/21 patients; nine were alive and well, four died of disease, and one died from other causes. Most tumors (16/21) showed predominantly classic morphology, comprised of alternating hyper- and hypocellular areas of primitive small cells and differentiating rhabdomyoblasts in a loose myxoid/edematous stroma.

A cambium layer was noted in all; seven had heterologous elements (six with fetal-type cartilage) and eight displayed focal anaplasia. The remaining five neoplasms showed only a minor component (≤20%) of classic morphology, with anaplasia noted in four and tumor cell necrosis in three. The most frequent mutations detected were in DICER1 (14/21), TP53 (7/20), PI3K/AKT/mTOR pathway (7/20), and KRAS/NRAS (5/20). Copy-number alterations were present in 10/19 tumors.

Overall, 8/14 DICER1-associated ucERMS showed concurrent loss of function and hotspot mutations in DICER1, which is a feature more likely to be seen in tumors associated with DICER1 syndrome.

Germline data were available for two patients, both DICER1 wild type (one with concurrent loss of function and hotspot alterations). DICER1-associated ucERMS were more likely to show a classic histological appearance including heterologous elements than DICER1-independent tumors.

No differences in survival were noted between the two groups, but both patients with extrauterine disease at diagnosis and two with recurrences died from disease. As no patients had a known personal or family history of DICER1 syndrome, we favor most DICER1-associated ucERMS to be sporadic.

 

Using molecular dynamics simulations to prioritize and understand AI-generated cell penetrating peptides

Cell-penetrating peptides have important therapeutic applications in drug delivery, but the variety of known cell-penetrating peptides is still limited. With a promise to accelerate peptide development, artificial intelligence (AI) techniques including deep generative models are currently in spotlight.

Scientists, however, are often overwhelmed by an excessive number of unannotated sequences generated by AI and find it difficult to obtain insights to prioritize them for experimental validation. To avoid this pitfall, we leverage molecular dynamics (MD) simulations to obtain mechanistic information to prioritize and understand AI-generated peptides.

A mechanistic score of permeability is computed from five steered MD simulations starting from different initial structures predicted by homology modelling. To compensate for variability of predicted structures, the score is computed with sample variance penalization so that a peptide with consistent behaviour is highly evaluated.

Our computational pipeline involving deep learning, homology modelling, MD simulations and synthesizability assessment generated 24 novel peptide sequences. The top-scoring peptide showed a consistent pattern of conformational change in all simulations regardless of initial structures.

As a result of wet-lab-experiments, our peptide showed better permeability and weaker toxicity in comparison to a clinically used peptide, TAT. Our result demonstrates how MD simulations can support de novo peptide design by providing mechanistic information supplementing statistical inference.

TNF α Mouse Monoclonal Antibody
E12-453	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

Flotillin-1 Mouse Monoclonal Antibody(6C10)
38095-100ul	SAB	100ul	EUR 302.4

Flotillin-1 Mouse Monoclonal Antibody(6C10)
38095-50ul	SAB	50ul	EUR 224.4

Flotillin-1 Mouse Monoclonal Antibody (6C10)
E038095	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

Flotillin-1 Mouse Monoclonal Antibody (6C10)
E12-197	EnoGene	100μg/100μlL	EUR 225
Description: Available in various conjugation types.

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)
44100-100ul	SAB	100ul	EUR 302.4

P44/42 MAPK (ERK1/2) Monoclonal Antibody (6C10)
E044100	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

TNF ? Monoclonal Antibody
EM1197-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

TNF ? Monoclonal Antibody
EM1197-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

Biotinylated Mouse TNF-α Monoclonal Antibody, Rabbit MAb（DET）
RM98000	Abclonal	100μg	Ask for price

P63-α Mouse Monoclonal Antibody (4C12)
E12-768	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

TNF Alpha Monoclonal Antibody
ABM40205-003ml	Abbkine	0.03ml	EUR 189.6
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody
ABM40205-01ml	Abbkine	0.1ml	EUR 346.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody
ABM40205-02ml	Abbkine	0.2ml	EUR 496.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody
ABM40206-003ml	Abbkine	0.03ml	EUR 189.6
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody
ABM40206-01ml	Abbkine	0.1ml	EUR 346.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody
ABM40206-02ml	Abbkine	0.2ml	EUR 496.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Monoclonal TNF Alpha Antibody (clone 2C8), Clone: 2C8
APR10497G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human TNF Alpha (clone 2C8). The antibodies are raised in Mouse and are from clone 2C8. This antibody is applicable in IHC-P

Mouse anti Rat TNF monoclonal antibody
CABT-L378	Creative Diagnostics	100ug	EUR 858

Mouse Monoclonal Antibody to TNF-alpha
E10-20161	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Mouse anti Canine TNF monoclonal antibody
CABT-L129	Creative Diagnostics	500ug	EUR 982.8

α-SMA Monoclonal Antibody
40482-100ul	SAB	100ul	EUR 302.4

α-SMA Monoclonal Antibody
40482-50ul	SAB	50ul	EUR 224.4

α-SMA Monoclonal Antibody
40495-100ul	SAB	100ul	EUR 302.4

α-SMA Monoclonal Antibody
40495-50ul	SAB	50ul	EUR 224.4

α-SMA Monoclonal Antibody
ABM0052-100uL	Abbkine	100 μL	EUR 229
Description: Mouse Anti-α-SMA Monoclonal Antibody

α-SMA Monoclonal Antibody
E040482	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody
E040495	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody
E20-53364	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody
E20-53365	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

Mouse anti Porcine TNF monoclonal antibody
CABT-L382	Creative Diagnostics	500ug	EUR 1008

Mouse anti Porcine TNF monoclonal antibody
CABT-L383	Creative Diagnostics	250 ug	EUR 1070.4

HSP90 α Monoclonal Antibody
E20-53480	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

HSP90 α Monoclonal Antibody
E20-53496	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

α-tubulin Monoclonal Antibody
E20-53035	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

α-tubulin Monoclonal Antibody
E20-53115	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

TNF Receptor II recombinant monoclonal antibody
A5046	Bimake	100ul X 3	EUR 714
Description: A recombinant monoclonal antibody from rabbit against human TNF Receptor II for WB,ELISA

Mouse anti Guinea Pig TNF monoclonal antibody
CABT-L155	Creative Diagnostics	500ug	EUR 982.8

Mouse anti Guinea Pig TNF monoclonal antibody
CABT-L156	Creative Diagnostics	250ug	EUR 1057.2

Rat anti Rhesus Macaque TNF monoclonal antibody
CABT-L376	Creative Diagnostics	500ug	EUR 982.8

Monoclonal TNF alpha Antibody, Clone: EP1085Y
APR10496G	Leading Biology	0.1ml	EUR 633.6
Description: A Monoclonal antibody against Human TNF alpha. The antibodies are raised in Rabbit and are from clone EP1085Y. This antibody is applicable in WB

Monoclonal TNF-alpha Antibody, Clone: 2A9B9
APR13767G	Leading Biology	0.1ml	EUR 580.8
Description: A Monoclonal antibody against Human TNF-alpha. The antibodies are raised in Mouse and are from clone 2A9B9. This antibody is applicable in WB, E

HSP90 α Monoclonal antibody(1F6)
44076-100ul	SAB	100ul	EUR 302.4

HSP90 α Monoclonal antibody(7D6)
44078-100ul	SAB	100ul	EUR 302.4

HSP90 α Monoclonal antibody (1F6)
E044076	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

HSP90 α Monoclonal antibody (7D6)
E044078	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

Tubulin α (9H4) monoclonal antibody
E43B8025	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Monoclonal FH Antibody (monoclonal) (M07), Clone: 5C12
AMM04543G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human FH (monoclonal) (M07). The antibodies are raised in mouse and are from clone 5C12. This antibody is applicable in WB and IF, E

α-tubulin Mouse Monoclonal Antibody
37981-100ul	SAB	100ul	EUR 302.4

α-tubulin Mouse Monoclonal Antibody
37981-50ul	SAB	50ul	EUR 224.4

α-tubulin Mouse Monoclonal Antibody
E037981	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

α-tubulin Mouse Monoclonal Antibody
E12-048	EnoGene	100μg/100μl	EUR 150
Description: Available in various conjugation types.

α-tubulin Mouse Monoclonal Antibody
E12-049	EnoGene	100μg/100μl	EUR 225
Description: Available in various conjugation types.

Monoclonal ENG Antibody (monoclonal) (M01), Clone: 4C11
AMM03494G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ENG (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C11. This antibody is applicable in WB, IP, E

Monoclonal TAZ Antibody (monoclonal) (M19), Clone: 3C10
APR10350G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human TAZ (monoclonal) (M19). The antibodies are raised in mouse and are from clone 3C10. This antibody is applicable in IF, E

Monoclonal RP2 Antibody (monoclonal) (M02), Clone: 5C10
APR13143G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human RP2 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 5C10. This antibody is applicable in WB, E

Monoclonal ID2 Antibody (monoclonal) (M04), Clone: 2C11
APR16801G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ID2 (monoclonal) (M04). The antibodies are raised in mouse and are from clone 2C11. This antibody is applicable in WB

IκB α Mouse Monoclonal Antibody (2A5)
E12-1051	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

PTEN (2C10) Monoclonal Antibody
EM1308-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Mouse Monoclonal antibody against PTEN (2C10) from Human. This antibody is tested and validated for IHC

PTEN (2C10) Monoclonal Antibody
EM1308-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Mouse Monoclonal antibody against PTEN (2C10) from Human. This antibody is tested and validated for IHC

Monoclonal SAA1 Antibody (monoclonal) (M01), Clone: 3C11-2C1
AMM04067G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SAA1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C11-2C1. This antibody is applicable in WB and IHC

Monoclonal GPD1 Antibody (monoclonal) (M01), Clone: 3C10-1C4
AMM05179G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GPD1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C10-1C4. This antibody is applicable in WB, E

Monoclonal FUT7 Antibody (monoclonal) (M03), Clone: 1C12
AMM03560G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human FUT7 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 1C12. This antibody is applicable in WB, E

Monoclonal GLMN Antibody (monoclonal) (M01), Clone: 1C12
AMM03583G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GLMN (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C12. This antibody is applicable in WB and IF, IP

Monoclonal ICT1 Antibody (monoclonal) (M06), Clone: 4C10
AMM03646G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ICT1 (monoclonal) (M06). The antibodies are raised in mouse and are from clone 4C10. This antibody is applicable in E

Monoclonal IL10 Antibody (monoclonal) (M03), Clone: 1C10
AMM03660G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human IL10 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 1C10. This antibody is applicable in WB

Monoclonal MID1 Antibody (monoclonal) (M06), Clone: 2C11
AMM03797G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MID1 (monoclonal) (M06). The antibodies are raised in mouse and are from clone 2C11. This antibody is applicable in WB

Monoclonal MRC1 Antibody (monoclonal) (M02), Clone: 5C11
AMM03811G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MRC1 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 5C11. This antibody is applicable in WB and IHC, E

Monoclonal ULK2 Antibody (monoclonal) (M01), Clone: 6C12
AMM08424G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ULK2 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C12. This antibody is applicable in WB, E

Monoclonal SGCB Antibody (monoclonal) (M02), Clone: 1C10
AMM07766G	Leading Biology	0.05mg	EUR 580.8
Description: A Monoclonal antibody against Human SGCB (monoclonal) (M02). The antibodies are raised in mouse and are from clone 1C10. This antibody is applicable in WB, IHC and IF, E

Monoclonal VAPA Antibody (monoclonal) (M01), Clone: 4C12
APR10689G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human VAPA (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C12. This antibody is applicable in WB and IF

Monoclonal ENC1 Antibody (monoclonal) (M03), Clone: 3C10
APR11826G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ENC1 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 3C10. This antibody is applicable in WB

Monoclonal SOX9 Antibody (monoclonal) (M02), Clone: 3C10
APR13498G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SOX9 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 3C10. This antibody is applicable in WB, IHC and IF, IP

Monoclonal NCF4 Antibody (monoclonal) (M01), Clone: 3C10
APR08620G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human NCF4 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C10. This antibody is applicable in E

Monoclonal PER2 Antibody (monoclonal) (M01), Clone: 5C10
APR09041G	Leading Biology	0.05mg	EUR 580.8
Description: A Monoclonal antibody against Human PER2 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 5C10. This antibody is applicable in WB, IHC and IF, E

Monoclonal RHOA Antibody (monoclonal) (M06), Clone: 1C10
AMM04010G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human RHOA (monoclonal) (M06). The antibodies are raised in mouse and are from clone 1C10. This antibody is applicable in WB and IF

Monoclonal TOE1 Antibody (monoclonal) (M02), Clone: 1C12
AMM04226G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human TOE1 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 1C12. This antibody is applicable in WB, IHC and IF

Monoclonal ETV5 Antibody (monoclonal) (M02), Clone: 7C10
AMM04466G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ETV5 (monoclonal) (M02). The antibodies are raised in Mouse and are from clone 7C10. This antibody is applicable in WB, E

Monoclonal FUT2 Antibody (monoclonal) (M02), Clone: 4C12
AMM04650G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human FUT2 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 4C12. This antibody is applicable in WB

Monoclonal GALT Antibody (monoclonal) (M01), Clone: 4C11
AMM04684G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GALT (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C11. This antibody is applicable in WB and IHC, E

Monoclonal GYG1 Antibody (monoclonal) (M08), Clone: 2C10
AMM05277G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GYG1 (monoclonal) (M08). The antibodies are raised in mouse and are from clone 2C10. This antibody is applicable in WB

P63-α Mouse Monoclonal Antibody (5A6)
E12-769	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

P63-α Mouse Monoclonal Antibody (7D9)
E12-771	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

P63-α Mouse Monoclonal Antibody (8E2)
E12-772	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

Monoclonal ZYX Antibody (monoclonal) (M01), Clone: 2C10-4A7
APR14058G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ZYX (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C10-4A7. This antibody is applicable in WB and IF, IP, E

Monoclonal PSMC2 Antibody (monoclonal) (M01), Clone: 4C10-2C8
AMM03955G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PSMC2 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C10-2C8. This antibody is applicable in WB and IF, E

Monoclonal CNAP1 Antibody (monoclonal) (M01), Clone: 4C12
AMM03400G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CNAP1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C12. This antibody is applicable in WB, IHC and IF, E

Monoclonal CSE1L Antibody (monoclonal) (M03), Clone: 2C10
AMM03419G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CSE1L (monoclonal) (M03). The antibodies are raised in mouse and are from clone 2C10. This antibody is applicable in WB, IHC and IF, E

Monoclonal FBXO8 Antibody (monoclonal) (M01), Clone: 1C11
AMM03533G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human FBXO8 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C11. This antibody is applicable in WB, E

Monoclonal GSDML Antibody (monoclonal) (M06), Clone: 4C10
AMM03598G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GSDML (monoclonal) (M06). The antibodies are raised in mouse and are from clone 4C10. This antibody is applicable in WB, E

Monoclonal HDAC1 Antibody (monoclonal) (M14), Clone: 5C11
AMM03610G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human HDAC1 (monoclonal) (M14). The antibodies are raised in mouse and are from clone 5C11. This antibody is applicable in WB, IHC and IF, E

Monoclonal MMP28 Antibody (monoclonal) (M01), Clone: 3C11
AMM03804G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MMP28 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C11. This antibody is applicable in WB, E

Monoclonal MS4A1 Antibody (monoclonal) (M01), Clone: 5C11
AMM03813G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MS4A1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 5C11. This antibody is applicable in WB, E

Monoclonal OTUB1 Antibody (monoclonal) (M09), Clone: 1C12
AMM03874G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human OTUB1 (monoclonal) (M09). The antibodies are raised in Mouse and are from clone 1C12. This antibody is applicable in WB, E

Monoclonal PCGF2 Antibody (monoclonal) (M04), Clone: 4C10
AMM03895G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PCGF2 (monoclonal) (M04). The antibodies are raised in mouse and are from clone 4C10. This antibody is applicable in WB

Monoclonal PDE3A Antibody (monoclonal) (M01), Clone: 5C12
AMM07052G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PDE3A (monoclonal) (M01). The antibodies are raised in mouse and are from clone 5C12. This antibody is applicable in WB, E

Monoclonal PPIL4 Antibody (monoclonal) (M01), Clone: 1C10
AMM07288G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PPIL4 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C10. This antibody is applicable in WB and IF

Monoclonal RAB43 Antibody (monoclonal) (M09), Clone: 4C11
AMM07480G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human RAB43 (monoclonal) (M09). The antibodies are raised in mouse and are from clone 4C11. This antibody is applicable in WB, E

Monoclonal RAMP3 Antibody (monoclonal) (M01), Clone: 1C11
AMM07513G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human RAMP3 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C11. This antibody is applicable in WB, E

Monoclonal SCAP1 Antibody (monoclonal) (M02), Clone: 1C11
AMM07727G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SCAP1 (monoclonal) (M02). The antibodies are raised in Mouse and are from clone 1C11. This antibody is applicable in WB, E

Monoclonal SNX12 Antibody (monoclonal) (M01), Clone: 2C10
AMM07906G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SNX12 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C10. This antibody is applicable in WB, E

Monoclonal GAP43 Antibody (monoclonal) (M01), Clone: 3C11
APR11999G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GAP43 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C11. This antibody is applicable in WB, E

Monoclonal SDCBP Antibody (monoclonal) (M01), Clone: 2C12
APR13235G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SDCBP (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C12. This antibody is applicable in WB, IHC and IF, IP

Monoclonal STAU1 Antibody (monoclonal) (M03), Clone: 3C12
APR13570G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human STAU1 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 3C12. This antibody is applicable in WB and IF, E

Monoclonal MAPK9 Antibody (monoclonal) (M03), Clone: 3C12
APR08334G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MAPK9 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 3C12. This antibody is applicable in WB and IF, E

Monoclonal MTHFS Antibody (monoclonal) (M01), Clone: 2C12
APR08551G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MTHFS (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C12. This antibody is applicable in WB

Monoclonal SMAD3 Antibody (monoclonal) (M09), Clone: 1C11
APR10163G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SMAD3 (monoclonal) (M09). The antibodies are raised in mouse and are from clone 1C11. This antibody is applicable in WB and IF, E

Monoclonal AKAP4 Antibody (monoclonal) (M02), Clone: 4C10
APR14896G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human AKAP4 (monoclonal) (M02). The antibodies are raised in Mouse and are from clone 4C10. This antibody is applicable in WB and IHC, E

Monoclonal BARX1 Antibody (monoclonal) (M05), Clone: 3C11
APR15115G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human BARX1 (monoclonal) (M05). The antibodies are raised in mouse and are from clone 3C11. This antibody is applicable in WB and IF, E

Monoclonal ITGA4 Antibody (monoclonal) (M01), Clone: 2C11
APR16914G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ITGA4 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C11. This antibody is applicable in WB, E

Monoclonal CETN1 Antibody (monoclonal) (M05), Clone: 4C12
APR15413G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CETN1 (monoclonal) (M05). The antibodies are raised in mouse and are from clone 4C12. This antibody is applicable in WB

Monoclonal FKBP4 Antibody (monoclonal) (M01), Clone: 5C11
APR15990G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human FKBP4 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 5C11. This antibody is applicable in WB and IHC, IP, E

Monoclonal MAPK6 Antibody (monoclonal) (M02), Clone: 4C11
APR17302G	Leading Biology	0.05mg	EUR 580.8
Description: A Monoclonal antibody against Human MAPK6 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 4C11. This antibody is applicable in WB and IF

Monoclonal OXSR1 Antibody (monoclonal) (M18), Clone: 4C12
APR17697G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human OXSR1 (monoclonal) (M18). The antibodies are raised in mouse and are from clone 4C12. This antibody is applicable in WB and IF, E

Monoclonal CLCA1 Antibody (monoclonal) (M03), Clone: 2C10
APG02621G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CLCA1 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 2C10. This antibody is applicable in WB, E

Monoclonal PRDX4 Antibody (monoclonal) (M01), Clone: 2C12
AMM03935G	Leading Biology	0.05mg	EUR 580.8
Description: A Monoclonal antibody against Human PRDX4 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C12. This antibody is applicable in WB and IHC

Monoclonal RAB4A Antibody (monoclonal) (M01), Clone: 1C10
AMM03978G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human RAB4A (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 1C10. This antibody is applicable in WB, E

Monoclonal RASA1 Antibody (monoclonal) (M01), Clone: 2C12
AMM03992G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human RASA1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C12. This antibody is applicable in WB and IHC, E

Monoclonal RUNX1 Antibody (monoclonal) (M06), Clone: 2C10
AMM04049G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human RUNX1 (monoclonal) (M06). The antibodies are raised in mouse and are from clone 2C10. This antibody is applicable in WB, IHC and IF, E

Monoclonal SNAI2 Antibody (monoclonal) (M05), Clone: 3C12
AMM04119G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SNAI2 (monoclonal) (M05). The antibodies are raised in mouse and are from clone 3C12. This antibody is applicable in WB and IF

Monoclonal TBX18 Antibody (monoclonal) (M04), Clone: 3C12
AMM04168G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human TBX18 (monoclonal) (M04). The antibodies are raised in mouse and are from clone 3C12. This antibody is applicable in WB

Monoclonal TGIF2 Antibody (monoclonal) (M01), Clone: 4C10
AMM04194G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human TGIF2 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C10. This antibody is applicable in WB, E

Monoclonal USP15 Antibody (monoclonal) (M01), Clone: 1C10
AMM04295G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human USP15 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C10. This antibody is applicable in WB and IF

Monoclonal FOXA2 Antibody (monoclonal) (M12), Clone: 6C12
AMM04593G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human FOXA2 (monoclonal) (M12). The antibodies are raised in Mouse and are from clone 6C12. This antibody is applicable in WB, IHC and IF, E

Monoclonal CSPG5 Antibody (monoclonal) (M01), Clone: 5C11
APG03231G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CSPG5 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 5C11. This antibody is applicable in WB, E

Monoclonal GPD2 Antibody (monoclonal) (M02), Clone: 2C11-1F4
AMRa00041G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GPD2 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 2C11-1F4. This antibody is applicable in WB, E

Monoclonal GNG7 Antibody (monoclonal) (M01), Clone: 1C11-1B3
AMM04835G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GNG7 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C11-1B3. This antibody is applicable in WB, E

P63-α Mouse Monoclonal Antibody (3F11)
E11-123797	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

P63-α Mouse Monoclonal Antibody (6E12)
E12-770	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

P63-α Mouse Monoclonal Antibody (9F12)
E12-773	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

P63-α Mouse Monoclonal Antibody (10H5)
E12-774	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

Monoclonal MAPK13 Antibody (monoclonal) (M01), Clone: 2C10-1C7
AMM03770G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MAPK13 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C10-1C7. This antibody is applicable in WB and IF

Monoclonal KCNJ10 Antibody (monoclonal) (M01), Clone: 1C11
AMM06100G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human KCNJ10 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C11. This antibody is applicable in WB, E

Monoclonal CAPN5 Antibody (monoclonal) (M02A), Clone: 3C10
AMM03318G	Leading Biology	0.1ml	EUR 580.8
Description: A Monoclonal antibody against Human CAPN5 (monoclonal) (M02A). The antibodies are raised in Mouse and are from clone 3C10. This antibody is applicable in WB

Monoclonal CDC14A Antibody (monoclonal) (M01), Clone: 2C12
AMM03354G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CDC14A (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C12. This antibody is applicable in WB and IF, E

Monoclonal FBXO11 Antibody (monoclonal) (M01), Clone: 4C12
AMM03527G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human FBXO11 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C12. This antibody is applicable in WB, IHC and IF, E

Monoclonal ISGF3G Antibody (monoclonal) (M01), Clone: 1C10
AMM03694G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ISGF3G (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C10. This antibody is applicable in WB and IHC, E

Monoclonal PGRMC2 Antibody (monoclonal) (M04), Clone: 3C11
AMM07133G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PGRMC2 (monoclonal) (M04). The antibodies are raised in mouse and are from clone 3C11. This antibody is applicable in WB and IHC, E

Monoclonal SREBF1 Antibody (monoclonal) (M02), Clone: 4C11
APR10239G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SREBF1 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 4C11. This antibody is applicable in WB, E

Monoclonal AKAP10 Antibody (monoclonal) (M04), Clone: 8C10
APR14894G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human AKAP10 (monoclonal) (M04). The antibodies are raised in mouse and are from clone 8C10. This antibody is applicable in WB and IHC, E

Monoclonal ANXA10 Antibody (monoclonal) (M02), Clone: 1C12
APR14944G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ANXA10 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 1C12. This antibody is applicable in E

Monoclonal KIF26A Antibody (monoclonal) (M01), Clone: 3C10
APR17003G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human KIF26A (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C10. This antibody is applicable in WB, E

Monoclonal AKR1C2 Antibody (monoclonal) (M03), Clone: 3C11
APG01662G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human AKR1C2 (monoclonal) (M03). The antibodies are raised in mouse and are from clone 3C11. This antibody is applicable in WB, E

Monoclonal AKR1C4 Antibody (monoclonal) (M01), Clone: 2C11
APG01666G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human AKR1C4 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C11. This antibody is applicable in WB, IHC and IF, E

Monoclonal CAMK2A Antibody (monoclonal) (M03), Clone: 2C12
APG02356G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CAMK2A (monoclonal) (M03). The antibodies are raised in mouse and are from clone 2C12. This antibody is applicable in WB and IF, E

Monoclonal SQSTM1 Antibody (monoclonal) (M01), Clone: 2C11
APR07188G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SQSTM1 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 2C11. This antibody is applicable in WB and IF, E

Monoclonal FCER1A Antibody (monoclonal) (M01), Clone: 2C12-3B6
AMM03535G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human FCER1A (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C12-3B6. This antibody is applicable in WB, E

Monoclonal ALDOA Antibody (monoclonal) (M02), Clone: 3C12-6D11
APG01799G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ALDOA (monoclonal) (M02). The antibodies are raised in mouse and are from clone 3C12-6D11. This antibody is applicable in WB and IF

Monoclonal RAPGEF4 Antibody (monoclonal) (M01), Clone: 1C11
AMM07530G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human RAPGEF4 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C11. This antibody is applicable in WB, E

Monoclonal PCDHGA8 Antibody (monoclonal) (M01), Clone: 1C11
APR12783G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PCDHGA8 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C11. This antibody is applicable in WB, E

Monoclonal PPP2R2B Antibody (monoclonal) (M01), Clone: 2C11
APR12944G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PPP2R2B (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C11. This antibody is applicable in WB

Monoclonal CTNNAL1 Antibody (monoclonal) (M05), Clone: 2C11
APR15626G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CTNNAL1 (monoclonal) (M05). The antibodies are raised in mouse and are from clone 2C11. This antibody is applicable in E

Monoclonal APEG1 Antibody (monoclonal) (M01), Clone: 2C2-2C7
AMM03267G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human APEG1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C2-2C7. This antibody is applicable in WB, E

Monoclonal CCL11 Antibody (monoclonal) (M01), Clone: 1C8-2C1
AMM03328G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human CCL11 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C8-2C1. This antibody is applicable in WB

Monoclonal STAT4 Antibody (monoclonal) (M01), Clone: 1C2-1C12
AMM04144G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human STAT4 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C2-1C12. This antibody is applicable in WB, IHC and IF, IP, E

Monoclonal PAFAH1B1 Antibody (monoclonal) (M01), Clone: 2C12
APR12703G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PAFAH1B1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C12. This antibody is applicable in WB, E

Monoclonal MGC40579 Antibody (monoclonal) (M11), Clone: 2C11
APR08430G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MGC40579 (monoclonal) (M11). The antibodies are raised in mouse and are from clone 2C11. This antibody is applicable in WB, E

Monoclonal PAFAH1B3 Antibody (monoclonal) (M02), Clone: 8C11
APR08918G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human PAFAH1B3 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 8C11. This antibody is applicable in WB and IF, E

Monoclonal SLC2A4RG Antibody (monoclonal) (M02), Clone: 4C10
APR10069G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human SLC2A4RG (monoclonal) (M02). The antibodies are raised in mouse and are from clone 4C10. This antibody is applicable in WB and IF

Monoclonal IL1RAPL1 Antibody (monoclonal) (M04), Clone: 1C10
APG03381G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human IL1RAPL1 (monoclonal) (M04). The antibodies are raised in mouse and are from clone 1C10. This antibody is applicable in WB, E

Anti-α-Tubulin Monoclonal Antibody (3G5)
ABL1080-200uL	Abbkine	200 μL	EUR 229
Description: Featured Anti-α-Tubulin Monoclonal Antibody (3G5), specially designed for your immunoassay as internal control or location staining.

Anti-α-Tubulin Monoclonal Antibody (3G5)
ABL1080-200uL5	Abbkine	200 μL×5	EUR 759
Description: Featured Anti-α-Tubulin Monoclonal Antibody (3G5), specially designed for your immunoassay as internal control or location staining.

Anti-α-Tubulin Monoclonal Antibody (3G5)
ABL1080-50uL	Abbkine	50 μL	EUR 79
Description: Featured Anti-α-Tubulin Monoclonal Antibody (3G5), specially designed for your immunoassay as internal control or location staining.

Monoclonal HBZ Antibody (monoclonal) (M01), Clone: 3C4-1D5
AMM03604G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human HBZ (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C4-1D5. This antibody is applicable in WB, E

Monoclonal VCL Antibody (monoclonal) (M01), Clone: 2C6-1B5
AMM04309G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human VCL (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C6-1B5. This antibody is applicable in WB and IF

EGFRvIII (2C10) monoclonal antibody
E43B8018	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Monoclonal C10orf4 Antibody (monoclonal) (M02), Clone: 2C4
AMM03293G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human C10orf4 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 2C4. This antibody is applicable in WB

Monoclonal DNAJB6 Antibody (monoclonal) (M01), Clone: 2C11-C1
APR11766G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human DNAJB6 (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 2C11-C1. This antibody is applicable in WB and IF, E

Monoclonal XPO5 Antibody (monoclonal) (M01), Clone: 2C5-1B3
AMM08531G	Leading Biology	0.05mg	EUR 580.8
Description: A Monoclonal antibody against Human XPO5 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C5-1B3. This antibody is applicable in WB and IF, IP, E

Monoclonal MASA Antibody (monoclonal) (M01), Clone: 3C1-1D5
APR08335G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MASA (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C1-1D5. This antibody is applicable in WB

Monoclonal KIAA0101 Antibody (monoclonal) (M01), Clone: 3C11-1F11
APR08093G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human KIAA0101 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C11-1F11. This antibody is applicable in WB, IHC and IF, E

Monoclonal F9 Antibody (monoclonal) (M01), Clone: 2C9
AMM03511G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human F9 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C9. This antibody is applicable in WB, IP, E

Monoclonal T Antibody (monoclonal) (M02), Clone: 5C5
AMM04164G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human T (monoclonal) (M02). The antibodies are raised in Mouse and are from clone 5C5. This antibody is applicable in WB, E

Monoclonal G22P1 Antibody (monoclonal) (M01), Clone: 4C2-1A6
AMM03567G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human G22P1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C2-1A6. This antibody is applicable in WB, IHC and IF, E

Monoclonal MPP1 Antibody (monoclonal) (M02), Clone: 1C3-1D11
AMM03809G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human MPP1 (monoclonal) (M02). The antibodies are raised in mouse and are from clone 1C3-1D11. This antibody is applicable in WB, E

Monoclonal THAP1 Antibody (monoclonal) (M01), Clone: 2C1-2F2
APR10467G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human THAP1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C1-2F2. This antibody is applicable in WB and IF

Monoclonal ENPP5 Antibody (monoclonal) (M01), Clone: 1C5-1D7
APR11831G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ENPP5 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C5-1D7. This antibody is applicable in WB

Monoclonal BAMBI Antibody (monoclonal) (M01), Clone: 3C1-1D1
APR15107G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human BAMBI (monoclonal) (M01). The antibodies are raised in Mouse and are from clone 3C1-1D1. This antibody is applicable in WB, E

Monoclonal UBE2H Antibody (monoclonal) (M01), Clone: 3C4-1A2
AMM04278G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human UBE2H (monoclonal) (M01). The antibodies are raised in mouse and are from clone 3C4-1A2. This antibody is applicable in WB and IF, E

Monoclonal GENX-3414 Antibody (monoclonal) (M11), Clone: 2C10
AMM03581G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human GENX-3414 (monoclonal) (M11). The antibodies are raised in mouse and are from clone 2C10. This antibody is applicable in WB

Monoclonal PDZK1 Antibody (monoclonal) (M01), Clone: 1C3-2B11
APR09031G	Leading Biology	0.05mg	EUR 580.8
Description: A Monoclonal antibody against Human PDZK1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C3-2B11. This antibody is applicable in WB and IHC, E

Monoclonal HDAC11 Antibody (monoclonal) (M01), Clone: 1C2-2G5
APR16678G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human HDAC11 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 1C2-2G5. This antibody is applicable in WB and IF, E

Monoclonal HSPE1 Antibody (monoclonal) (M01), Clone: 4C11-B11
APR07842G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human HSPE1 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C11-B11. This antibody is applicable in WB and IF, E

Monoclonal UBE2D3 Antibody (monoclonal) (M01), Clone: 4C1-1E3
AMM04274G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human UBE2D3 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 4C1-1E3. This antibody is applicable in WB, E

α skeletal muscle actin Monoclonal Antibody
E20-53149	EnoGene	100ug	EUR 225
Description: Available in various conjugation types.

GSK3? (2C6) Monoclonal Antibody
EM1283-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Mouse Monoclonal antibody against GSK3? (2C6) from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

GSK3? (2C6) Monoclonal Antibody
EM1283-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Mouse Monoclonal antibody against GSK3? (2C6) from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

NBR1 (7C3) Monoclonal Antibody
EM1373-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Mouse Monoclonal antibody against NBR1 (7C3) from Human/ Mouse/ Rat. This antibody is tested and validated for IHC

NBR1 (7C3) Monoclonal Antibody
EM1373-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Mouse Monoclonal antibody against NBR1 (7C3) from Human/ Mouse/ Rat. This antibody is tested and validated for IHC

ATG5 (3C7) Monoclonal Antibody
EM1374-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Mouse Monoclonal antibody against ATG5 (3C7) from Human/ Mouse/ Rat. This antibody is tested and validated for WB, ELISA, IHC

ATG5 (3C7) Monoclonal Antibody
EM1374-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Mouse Monoclonal antibody against ATG5 (3C7) from Human/ Mouse/ Rat. This antibody is tested and validated for WB, ELISA, IHC

Monoclonal ARHGDIB Antibody (monoclonal) (M01), Clone: 2C12-B6
APR15024G	Leading Biology	0.1mg	EUR 580.8
Description: A Monoclonal antibody against Human ARHGDIB (monoclonal) (M01). The antibodies are raised in mouse and are from clone 2C12-B6. This antibody is applicable in E

Smad3 (4C9) Monoclonal Antibody
EM1315-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Mouse Monoclonal antibody against Smad3 (4C9) from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

Smad3 (4C9) Monoclonal Antibody
EM1315-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Mouse Monoclonal antibody against Smad3 (4C9) from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

CD106/VCAM1 (2C11) monoclonal antibody
E43B8559	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Sex-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion

Purpose: We previously demonstrated that sex influences response tovimmune-checkpoint inhibitors. Here we investigate sex-based differences in the molecular mechanisms of anticancer immune-response and immune evasion in patients with NSCLC.

Experimental design: We analyzed a) transcriptome-data of 2575 early-stage NSCLCs from 7 different datasets; b) 327 tumor-samples extensively characterized at the molecular level from the TRACERx lung study; c) two independent cohorts of respectively 329 and 391 patients with advanced NSCLC treated with anti-PD1/anti-PDL1 drugs.

Results: As compared with men, the tumor microenvironment (TME) of women was significantly enriched for a number of innate and adaptive immune cell-types, including specific T-cell subpopulations. NSCLCs of men and women exploited different mechanisms of immune evasion.

The TME of females was characterized by significantly greater T-cell dysfunction status, higher expression of inhibitory immune-checkpoint molecules and higher abundance of immune-suppressive cells, including Cancer Associated Fibroblasts, MDSCs and Regulatory T-cells. By contrast, the TME of males was significantly enriched for a T-cells excluded phenotype.

We reported data supporting impaired neoantigens presentation to immune system in tumors of men, as molecular mechanism explaining the findings observed. Finally, in line with our results, we showed significant sex-based differences in the association between TMB and outcome of patients with advanced NSCLC treated with anti-PD1/PDL1 drugs.

Conclusions: We demonstrated meaningful sex-based differences of anticancer immune response and immune evasion mechanisms, that may be exploited to improve immunotherapy efficacy for both women and men.

Serum high-molecular-weight adiponectin and response to dapagliflozin in patients with type 2 diabetes and non-alcoholic fatty liver disease

A better baseline renal function is associated with a better response to sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes. Low serum adiponectin is associated with visceral fat accumulation and hepatic steatosis.

• We investigated the relationship between baseline serum adiponectin and glycemic response to dapagliflozin in patients with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). In a randomized, active-controlled, open-label trial, 57 patients with type 2 diabetes and NAFLD were randomized to either the dapagliflozin (5 mg/d) group or the control group.
• Both groups were treated for 24 weeks. Serum high-molecular-weight (HMW) adiponectin was measured with an ELISA kit. Visceral fat area (VFA) was measured by dual bioelectrical impedance analysis.
• Hepatic steatosis was assessed by the controlled attenuation parameter (CAP) measured by a transient elastography (FibroScan). Treatment with dapagliflozin significantly decreased HbA1c from 8.4%±1.5% at baseline to 7.4%±1.2% at 24 weeks. Both VFA and CAP decreased in the dapagliflozin group.
• Baseline serum HMW adiponectin was negatively correlated with changes in HbA1c from baseline to 24 weeks with dapagliflozin therapy. In the multivariate analysis, baseline HbA1c (β=-0.559, p=0.002) and serum HMW adiponectin (β=0.471, p=0.010) were independent determinants for the change (reduction) in HbA1c.
• In the dapagliflozin group, the change in HbA1c was positively correlated with the changes of CAP, but negatively correlated with the change in serum HMW adiponectin. In conclusion, a lower serum level of HMW adiponectin was associated with a better response to dapagliflozin in patients with type 2 diabetes and NAFLD.Trial registration numberUMIN000022155.