Sex-based dimorphism of anticancer immune response and molecular mechanisms

Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations

Herein we evaluated a series of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a rare neoplasm, to characterize their morphology, genomics, and behavior. Patients ranged from 27 to 73 (median 52) years and tumors from 4 to 15 (median 9) cm, with extrauterine disease noted in two.

Follow-up (median 16 months) was available for 14/21 patients; nine were alive and well, four died of disease, and one died from other causes. Most tumors (16/21) showed predominantly classic morphology, comprised of alternating hyper- and hypocellular areas of primitive small cells and differentiating rhabdomyoblasts in a loose myxoid/edematous stroma.

A cambium layer was noted in all; seven had heterologous elements (six with fetal-type cartilage) and eight displayed focal anaplasia. The remaining five neoplasms showed only a minor component (≤20%) of classic morphology, with anaplasia noted in four and tumor cell necrosis in three. The most frequent mutations detected were in DICER1 (14/21), TP53 (7/20), PI3K/AKT/mTOR pathway (7/20), and KRAS/NRAS (5/20). Copy-number alterations were present in 10/19 tumors.

Overall, 8/14 DICER1-associated ucERMS showed concurrent loss of function and hotspot mutations in DICER1, which is a feature more likely to be seen in tumors associated with DICER1 syndrome.

Germline data were available for two patients, both DICER1 wild type (one with concurrent loss of function and hotspot alterations). DICER1-associated ucERMS were more likely to show a classic histological appearance including heterologous elements than DICER1-independent tumors.

No differences in survival were noted between the two groups, but both patients with extrauterine disease at diagnosis and two with recurrences died from disease. As no patients had a known personal or family history of DICER1 syndrome, we favor most DICER1-associated ucERMS to be sporadic.

 

Using molecular dynamics simulations to prioritize and understand AI-generated cell penetrating peptides

Cell-penetrating peptides have important therapeutic applications in drug delivery, but the variety of known cell-penetrating peptides is still limited. With a promise to accelerate peptide development, artificial intelligence (AI) techniques including deep generative models are currently in spotlight.

Scientists, however, are often overwhelmed by an excessive number of unannotated sequences generated by AI and find it difficult to obtain insights to prioritize them for experimental validation. To avoid this pitfall, we leverage molecular dynamics (MD) simulations to obtain mechanistic information to prioritize and understand AI-generated peptides.

A mechanistic score of permeability is computed from five steered MD simulations starting from different initial structures predicted by homology modelling. To compensate for variability of predicted structures, the score is computed with sample variance penalization so that a peptide with consistent behaviour is highly evaluated.

Our computational pipeline involving deep learning, homology modelling, MD simulations and synthesizability assessment generated 24 novel peptide sequences. The top-scoring peptide showed a consistent pattern of conformational change in all simulations regardless of initial structures.

As a result of wet-lab-experiments, our peptide showed better permeability and weaker toxicity in comparison to a clinically used peptide, TAT. Our result demonstrates how MD simulations can support de novo peptide design by providing mechanistic information supplementing statistical inference.

xceedmolecular
xceedmolecular

TNF α Monoclonal antibody (Q36)

E044074 100μg/100μl
EUR 255
Description: Available in various conjugation types.

TNF α Monoclonal Antibody(Q34)

E44H11100 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF α Monoclonal Antibody(Q36)

E44H11101 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Monoclonal TXN Antibody (monoclonal) (M04), Clone: 6C10

APR10588G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human TXN (monoclonal) (M04). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB and IF, E

Flotillin-1 Monoclonal Antibody(6C10)

BT-MCA0561-100ul 100ul Ask for price
Description: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

Flotillin-1 Monoclonal Antibody(6C10)

BT-MCA0561-20ul 20ul Ask for price
Description: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

Flotillin-1 Monoclonal Antibody(6C10)

BT-MCA0561-50ul 50ul Ask for price
Description: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

Flotillin-1 Monoclonal Antibody(6C10)

E44H10807 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Flotillin-1 Monoclonal Antibody (6C10)

MBS9241481-01mL 0.1mL
EUR 425

Flotillin-1 Monoclonal Antibody (6C10)

MBS9241481-5x01mL 5x0.1mL
EUR 1887

Monoclonal STAT6 Antibody (monoclonal) (M01), Clone: 6C10

AMM04145G 0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human STAT6 (monoclonal) (M01). The antibodies are raised in mouse and are from clone 6C10. This antibody is applicable in WB, IHC and IF, E

TNF α Mouse Monoclonal Antibody

E12-452 100μg/100μl
EUR 255
Description: Available in various conjugation types.

TNF α Mouse Monoclonal Antibody

E12-453 100μg/100μl
EUR 255
Description: Available in various conjugation types.

TNF α Mouse Monoclonal Antibody

EM1197-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

TNF α Mouse Monoclonal Antibody

EM1197-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against TNF ? from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

Flotillin Mouse Monoclonal Antibody(6C10)

38095 100ul
EUR 319

Flotillin-1 Mouse Monoclonal Antibody(6C10)

38095-100ul 100ul
EUR 302.4

Flotillin-1 Mouse Monoclonal Antibody(6C10)

38095-50ul 50ul
EUR 224.4

Flotillin-1 Mouse Monoclonal Antibody (6C10)

E038095 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Flotillin-1 Mouse Monoclonal Antibody (6C10)

E12-197 100μg/100μlL
EUR 225
Description: Available in various conjugation types.

Flotillin-1 Mouse Monoclonal Antibody(6C10)

RA10006-100ul 100 ul
EUR 298

Flotillin-1 Mouse Monoclonal Antibody(6C10)

RA10006-50ul 50 ul
EUR 198

Flotillin-1 Mouse Monoclonal Antibody(6C10)

MBS9400280-01mL 0.1mL
EUR 305

Flotillin-1 Mouse Monoclonal Antibody(6C10)

MBS9400280-5x01mL 5x0.1mL
EUR 1230

Flotillin-1 Mouse Monoclonal Antibody (6C10)

MBS8500304-01mg 0.1mg
EUR 305

Flotillin-1 Mouse Monoclonal Antibody (6C10)

MBS8500304-01mLAF405L 0.1mL(AF405L)
EUR 465

Flotillin-1 Mouse Monoclonal Antibody (6C10)

MBS8500304-01mLAF405S 0.1mL(AF405S)
EUR 465

Flotillin-1 Mouse Monoclonal Antibody (6C10)

MBS8500304-01mLAF610 0.1mL(AF610)
EUR 465

Flotillin-1 Mouse Monoclonal Antibody (6C10)

MBS8500304-01mLAF635 0.1mL(AF635)
EUR 465

TNF α Mouse Monoclonal Antibody(Q34)

RA10029-100ul 100 ul
EUR 298

TNF α Mouse Monoclonal Antibody(Q34)

RA10029-50ul 50 ul
EUR 198

TNF α Mouse Monoclonal Antibody(Q36)

RA10030-100ul 100 ul
EUR 298

TNF α Mouse Monoclonal Antibody(Q36)

RA10030-50ul 50 ul
EUR 198

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

44100 100ul
EUR 319

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

44100-100ul 100ul
EUR 302.4

P44/42 MAPK (ERK1/2) Monoclonal Antibody (6C10)

E044100 100μg/100μl
EUR 255
Description: Available in various conjugation types.

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

BT-MCA0974-100ul 100ul Ask for price
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

BT-MCA0974-20ul 20ul Ask for price
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

BT-MCA0974-50ul 50ul Ask for price
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

E44H11141 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

P44/42 MAPK (ERK1/2) Monoclonal Antibody (6C10)

MBS9241705-01mL 0.1mL
EUR 425

P44/42 MAPK (ERK1/2) Monoclonal Antibody (6C10)

MBS9241705-5x01mL 5x0.1mL
EUR 1887

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

MBS9417501-005mL 0.05mL
EUR 245

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

MBS9417501-01mL 0.1mL
EUR 305

P44/42 MAPK (ERK1/2) Monoclonal Antibody(6C10)

MBS9417501-5x01mL 5x0.1mL
EUR 1230

P44 42 MAPK(ERK1 2) Mouse Monoclonal Antibody(6C10)

RA10052-100ul 100 ul
EUR 298

P44 42 MAPK(ERK1 2) Mouse Monoclonal Antibody(6C10)

RA10052-50ul 50 ul
EUR 198

TNF alpha (TNF) mouse monoclonal antibody, clone 2C8

4T10-2C8 1 mg Ask for price

CD4 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA802096 100 µl Ask for price

CD4 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA802096S 30 µl Ask for price

GFI1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA807139 100 µl Ask for price

GFI1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA807139S 30 µl Ask for price

PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA803949 100 µl Ask for price

PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA803949S 30 µl Ask for price

ENKUR mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA804173 100 µl Ask for price

ENKUR mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA804173S 30 µl Ask for price

FBXO21 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA503996 100 µl Ask for price

FBXO21 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA503996S 30 µl Ask for price

Mouse Anti-Rat TNF-α Monoclonal Antibody, clone 56529

CABT-Z181R 100 µg; 500 µg Ask for price
Description: Mouse

Anti-ATP5B mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA500838 100 µl Ask for price

Anti-ATP5B mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA500838S 30 µl Ask for price

Biotinylated Mouse TNF-α Monoclonal Antibody, Rabbit MAb(DET)

RM98000 100μg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 2C8, Aff - Purified

AM26058PU-N 100 µg Ask for price

Mouse Anti-Human TNF-α monoclonal antibody, clone C-G8

CABT-ZB421 200 µg
EUR 810
Description: Mouse

Mouse Anti-Human TNF-α monoclonal antibody, clone C-D8

CABT-ZB423 200 µg
EUR 810
Description: Mouse

P63-α Mouse Monoclonal Antibody (4C12)

E12-768 100μg/100μl
EUR 255
Description: Available in various conjugation types.

P63-α Mouse Monoclonal Antibody(4C12)

RA10254-100ul 100 ul
EUR 298

P63-α Mouse Monoclonal Antibody(4C12)

RA10254-50ul 50 ul
EUR 198

TNF alpha (TNF) mouse monoclonal antibody, clone 4C6-H8, Purified

AM33351PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 4C6-H8, Purified

AM33351PU-T 20 µg Ask for price

TNF Monoclonal Antibody

MBS7135234-005mg 0.05mg
EUR 150

TNF Monoclonal Antibody

MBS7135234-01mg 0.1mg
EUR 190

TNF Monoclonal Antibody

MBS7135234-5x01mg 5x0.1mg
EUR 845

TNF Monoclonal Antibody

MBS7135235-005mg 0.05mg
EUR 150

TNF Monoclonal Antibody

MBS7135235-01mg 0.1mg
EUR 190

TNF Monoclonal Antibody

MBS7135235-5x01mg 5x0.1mg
EUR 845

Anti-LEMD3 (MAN1) mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA500794 100 µl Ask for price

Anti-LEMD3 (MAN1) mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

TA500794S 30 µl Ask for price

Recombinant Mouse Anti-Rat TNF-α Monoclonal Antibody, clone 56529S

CABT-Z180R 100 µg; 500 µg Ask for price
Description: Mouse

TNF alpha (TNF) (115-130) mouse monoclonal antibody, clone 4C6-H6, Supernatant

SM1330 2 ml Ask for price

Monoclonal TNF Alpha Antibody (clone 2C8), Clone: 2C8

APR10497G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human TNF Alpha (clone 2C8). The antibodies are raised in Mouse and are from clone 2C8. This antibody is applicable in IHC-P

TNF Alpha Monoclonal Antibody

ABM40205-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40205-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40205-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

ABM40206-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of TNF Alpha from Human, Mouse, Rat. This TNF Alpha antibody is for WB, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

TNF Alpha Monoclonal Antibody

BT-MCA1212-100ul 100ul Ask for price
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

TNF Alpha Monoclonal Antibody

BT-MCA1212-50ul 50ul Ask for price
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

TNF alpha Monoclonal Antibody

E-AB-22116-120uL 120uL
EUR 240
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22116-200uL 200uL
EUR 399
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22116-20uL 20uL
EUR 73
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22116-60uL 60uL
EUR 143
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22159-120uL 120uL
EUR 240
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22159-200uL 200uL
EUR 399
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22159-20uL 20uL
EUR 73
Description: Unconjugated

TNF alpha Monoclonal Antibody

E-AB-22159-60uL 60uL
EUR 143
Description: Unconjugated

TNF alpha Monoclonal Antibody

MBS8519657-01mg 0.1mg
EUR 305

TNF alpha Monoclonal Antibody

MBS8519657-01mLAF405L 0.1mL(AF405L)
EUR 465

TNF alpha Monoclonal Antibody

MBS8519657-01mLAF405S 0.1mL(AF405S)
EUR 465

TNF alpha Monoclonal Antibody

MBS8519657-01mLAF610 0.1mL(AF610)
EUR 465

TNF alpha Monoclonal Antibody

MBS8519657-01mLAF635 0.1mL(AF635)
EUR 465

TNF alpha Monoclonal Antibody

MBS8519658-01mg 0.1mg
EUR 305

TNF alpha Monoclonal Antibody

MBS8519658-01mLAF405L 0.1mL(AF405L)
EUR 465

TNF alpha Monoclonal Antibody

MBS8519658-01mLAF405S 0.1mL(AF405S)
EUR 465

TNF alpha Monoclonal Antibody

MBS8519658-01mLAF610 0.1mL(AF610)
EUR 465

TNF alpha Monoclonal Antibody

MBS8519658-01mLAF635 0.1mL(AF635)
EUR 465

TNF alpha Monoclonal Antibody

MBS2548893-002mL 0.02mL
EUR 135

TNF alpha Monoclonal Antibody

MBS2548893-006mL 0.06mL
EUR 190

TNF alpha Monoclonal Antibody

MBS2548893-012mL 0.12mL
EUR 265

TNF alpha Monoclonal Antibody

MBS2548893-02mL 0.2mL
EUR 415

TNF alpha Monoclonal Antibody

MBS2548893-5x02mL 5x0.2mL
EUR 1835

TNF alpha Monoclonal Antibody

MBS2548932-002mL 0.02mL
EUR 135

TNF alpha Monoclonal Antibody

MBS2548932-006mL 0.06mL
EUR 190

TNF alpha Monoclonal Antibody

MBS2548932-012mL 0.12mL
EUR 265

TNF alpha Monoclonal Antibody

MBS2548932-02mL 0.2mL
EUR 415

TNF alpha Monoclonal Antibody

MBS2548932-5x02mL 5x0.2mL
EUR 1835

TNF alpha Monoclonal Antibody

RD85537A-120uL 120μL
EUR 360
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

TNF alpha Monoclonal Antibody

RD85537A-200uL 200μL
EUR 630
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

TNF alpha Monoclonal Antibody

RD85537A-20uL 20μL
EUR 109.5
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

TNF alpha Monoclonal Antibody

RD85537A-60uL 60μL
EUR 214.5
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

TNF alpha Monoclonal Antibody

MBS9700322-01mL 0.1mL
EUR 215

TNF alpha Monoclonal Antibody

MBS9700322-5x01mL 5x0.1mL
EUR 925

TNF alpha Monoclonal Antibody

RD85588A-120uL 120μL
EUR 360
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

TNF alpha Monoclonal Antibody

RD85588A-200uL 200μL
EUR 630
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

TNF alpha Monoclonal Antibody

RD85588A-20uL 20μL
EUR 109.5
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

TNF alpha Monoclonal Antibody

RD85588A-60uL 60μL
EUR 214.5
Description: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

TNF-alpha (human) monoclonal antibody (TNF-D)

MBS566313-01mg 0.1mg
EUR 410

TNF-alpha (human) monoclonal antibody (TNF-D)

MBS566313-5x01mg 5x0.1mg
EUR 1795

TNF mouse monoclonal antibody, clone OTI1C1 (formerly 1C1)

TA506513 100 µl Ask for price

TNF mouse monoclonal antibody, clone OTI1C1 (formerly 1C1)

TA506513S 30 µl Ask for price

TNF mouse monoclonal antibody, clone CC327, Purified

SM2216P 500 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 1D9

4T10-1D9 1 mg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone F6C5

4T10-F6C5 1 mg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, Azide Free

PM1012A 500 µg Ask for price

TNF Alpha Monoclonal Antibody(Q34)

BT-MCA1210-100ul 100ul Ask for price
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

TNF Alpha Monoclonal Antibody(Q34)

BT-MCA1210-20ul 20ul Ask for price
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

TNF Alpha Monoclonal Antibody(Q34)

BT-MCA1210-50ul 50ul Ask for price
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

TNF Alpha Monoclonal Antibody(Q36)

BT-MCA1211-100ul 100ul Ask for price
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

TNF Alpha Monoclonal Antibody(Q36)

BT-MCA1211-20ul 20ul Ask for price
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

TNF Alpha Monoclonal Antibody(Q36)

BT-MCA1211-50ul 50ul Ask for price
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

TNF alpha Monoclonal Antibody (Q36)

MBS9241671-01mL 0.1mL
EUR 425

TNF alpha Monoclonal Antibody (Q36)

MBS9241671-5x01mL 5x0.1mL
EUR 1887

TNF alpha Monoclonal antibody(Q34)

MBS9417474-005mL 0.05mL
EUR 245

TNF alpha Monoclonal antibody(Q34)

MBS9417474-01mL 0.1mL
EUR 305

TNF alpha Monoclonal antibody(Q34)

MBS9417474-5x01mL 5x0.1mL
EUR 1230

TNF alpha Monoclonal antibody(Q36)

MBS9417475-005mL 0.05mL
EUR 245

TNF alpha Monoclonal antibody(Q36)

MBS9417475-01mL 0.1mL
EUR 305

TNF alpha Monoclonal antibody(Q36)

MBS9417475-5x01mL 5x0.1mL
EUR 1230

TNF alpha Mouse Monoclonal Antibody

E10G20443 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF alpha Mouse Monoclonal Antibody

E10G20455 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF alpha Mouse Monoclonal Antibody

E10G20462 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

TNF alpha Mouse Monoclonal Antibody

MBS8510473-01mg 0.1mg
EUR 325

TNF alpha Mouse Monoclonal Antibody

MBS8510473-01mLAF405L 0.1mL(AF405L)
EUR 465

TNF alpha Mouse Monoclonal Antibody

MBS8510473-01mLAF405S 0.1mL(AF405S)
EUR 465

TNF alpha Mouse Monoclonal Antibody

MBS8510473-01mLAF610 0.1mL(AF610)
EUR 465

TNF alpha Mouse Monoclonal Antibody

MBS8510473-01mLAF635 0.1mL(AF635)
EUR 465

TNF alpha Mouse Monoclonal Antibody

MBS8510474-01mg 0.1mg
EUR 325

TNF alpha Mouse Monoclonal Antibody

MBS8510474-01mLAF405L 0.1mL(AF405L)
EUR 465

TNF alpha Mouse Monoclonal Antibody

MBS8510474-01mLAF405S 0.1mL(AF405S)
EUR 465

TNF alpha Mouse Monoclonal Antibody

MBS8510474-01mLAF610 0.1mL(AF610)
EUR 465

TNF alpha Mouse Monoclonal Antibody

MBS8510474-01mLAF635 0.1mL(AF635)
EUR 465

TNF alpha (TNF) mouse monoclonal antibody, clone T1, FITC

AM26289FC-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF706, Purified

AM50317PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF706, Purified

AM50317PU-T 20 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF655, Purified

AM50319PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF655, Purified

AM50319PU-T 20 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF656, Purified

AM50320PU-S 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone TNF656, Purified

AM50320PU-T 20 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone B1E4, HRP

AM09183HR-N 200 µl Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab11, PE

AM26711RP-N 100 Tests Ask for price

Carrier-free (BSA/glycerol-free) CD4 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF802096 100 µg Ask for price

Carrier-free (glycerol/BSA-free) GFI1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF807139 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T3, Biotin

AM26288BT-N 50 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone T1, Biotin

AM26289BT-N 50 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab11, APC

AM26711AC-N 100 Tests Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone 52B83, FITC

AM26298FC-N 100 µg Ask for price

TNF alpha (TNF) mouse monoclonal antibody, clone Mab11, FITC

AM26711FC-N 100 Tests Ask for price

α-SMA Monoclonal Antibody

40482 100ul
EUR 319

α-SMA Monoclonal Antibody

40482-100ul 100ul
EUR 302.4

α-SMA Monoclonal Antibody

40482-50ul 50ul
EUR 224.4

α-SMA Monoclonal Antibody

40495-100ul 100ul
EUR 302.4

α-SMA Monoclonal Antibody

40495-50ul 50ul
EUR 224.4

α-SMA Monoclonal Antibody

E040482 100μg/100μl
EUR 255
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody

E040495 100μg/100μl
EUR 255
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody

E20-53364 100ug
EUR 225
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody

E20-53365 100ug
EUR 225
Description: Available in various conjugation types.

α-SMA Monoclonal Antibody

ABM0052-100uL 100 μL
EUR 229
Description: Mouse Anti-α-SMA Monoclonal Antibody

α-SMA Monoclonal Antibody

ABM0052-each each Ask for price

α-SMA Monoclonal Antibody

ABM0052-Null Null Ask for price

Carrier-free (BSA/glycerol-free) FBXO21 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF503996 100 µg Ask for price

Carrier-free (BSA/glycerol-free) LEMD3 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF500794 100 µg Ask for price

Carrier-free (BSA/glycerol-free) ATP5B mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF500838 100 µg Ask for price

Carrier-free (BSA/glycerol-free) PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF803949 100 µg Ask for price

Carrier-free (BSA/glycerol-free) ENKUR mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)

CF804173 100 µg Ask for price

Sex-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion

Purpose: We previously demonstrated that sex influences response tovimmune-checkpoint inhibitors. Here we investigate sex-based differences in the molecular mechanisms of anticancer immune-response and immune evasion in patients with NSCLC.

Experimental design: We analyzed a) transcriptome-data of 2575 early-stage NSCLCs from 7 different datasets; b) 327 tumor-samples extensively characterized at the molecular level from the TRACERx lung study; c) two independent cohorts of respectively 329 and 391 patients with advanced NSCLC treated with anti-PD1/anti-PDL1 drugs.

Results: As compared with men, the tumor microenvironment (TME) of women was significantly enriched for a number of innate and adaptive immune cell-types, including specific T-cell subpopulations. NSCLCs of men and women exploited different mechanisms of immune evasion.

The TME of females was characterized by significantly greater T-cell dysfunction status, higher expression of inhibitory immune-checkpoint molecules and higher abundance of immune-suppressive cells, including Cancer Associated Fibroblasts, MDSCs and Regulatory T-cells. By contrast, the TME of males was significantly enriched for a T-cells excluded phenotype.

We reported data supporting impaired neoantigens presentation to immune system in tumors of men, as molecular mechanism explaining the findings observed. Finally, in line with our results, we showed significant sex-based differences in the association between TMB and outcome of patients with advanced NSCLC treated with anti-PD1/PDL1 drugs.

Conclusions: We demonstrated meaningful sex-based differences of anticancer immune response and immune evasion mechanisms, that may be exploited to improve immunotherapy efficacy for both women and men.

Serum high-molecular-weight adiponectin and response to dapagliflozin in patients with type 2 diabetes and non-alcoholic fatty liver disease

A better baseline renal function is associated with a better response to sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes. Low serum adiponectin is associated with visceral fat accumulation and hepatic steatosis.

  • We investigated the relationship between baseline serum adiponectin and glycemic response to dapagliflozin in patients with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). In a randomized, active-controlled, open-label trial, 57 patients with type 2 diabetes and NAFLD were randomized to either the dapagliflozin (5 mg/d) group or the control group.
  • Both groups were treated for 24 weeks. Serum high-molecular-weight (HMW) adiponectin was measured with an ELISA kit. Visceral fat area (VFA) was measured by dual bioelectrical impedance analysis.
  • Hepatic steatosis was assessed by the controlled attenuation parameter (CAP) measured by a transient elastography (FibroScan). Treatment with dapagliflozin significantly decreased HbA1c from 8.4%±1.5% at baseline to 7.4%±1.2% at 24 weeks. Both VFA and CAP decreased in the dapagliflozin group.
  • Baseline serum HMW adiponectin was negatively correlated with changes in HbA1c from baseline to 24 weeks with dapagliflozin therapy. In the multivariate analysis, baseline HbA1c (β=-0.559, p=0.002) and serum HMW adiponectin (β=0.471, p=0.010) were independent determinants for the change (reduction) in HbA1c.
  • In the dapagliflozin group, the change in HbA1c was positively correlated with the changes of CAP, but negatively correlated with the change in serum HMW adiponectin. In conclusion, a lower serum level of HMW adiponectin was associated with a better response to dapagliflozin in patients with type 2 diabetes and NAFLD.Trial registration numberUMIN000022155.

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